碘油联合Embosphere微球对肝癌患者TACE疗效及预后的影响(1)
[摘要] 目的 探討碘油联合Embosphere微球对行TACE肝癌患者的疗效及预后。 方法 选取南通大学附属医院2010年1月～2012年6月接收的肝癌患者62例作为研究对象，随机分为对照组与联合组，对照组患者TACE治疗中使用碘油栓塞，联合组使用碘油联合Embosphere微球栓塞，对比两组患者治疗前后肿瘤体积变化、治疗前及治疗后4周的甲胎蛋白(AFP)、肝功指标水平，并对1、3、5年生存率及不良反应发生率进行统计。 结果 联合组患者治疗后肿瘤体积明显小于对照组(P < 0.05)；两组患者治疗后血清AFP水平较治疗前均显著下降(P < 0.05)，联合组患者治疗后血清AFP水平低于对照组(P < 0.05)；治疗后两组患者谷丙转氨酶(ALT)水平比较，差异无统计学意义(P > 0.05)；联合组患者治疗后谷草转氨酶(AST)、总胆红素(TBIL)、白蛋白(ALB)水平与对照组比较，差异有统计学意义(P < 0.05)；联合组患者治疗后平均生存时间为(47.21±6.32)个月，中位生存时间为(56.42±6.36)个月；对照组平均生存时间为(30.65±4.52)个月，中位生存时间位(18.69±4.38)个月；两组患者治疗后1、3、5年生存率比较，差异有统计学意义(P < 0.05)；对照组患者不良反应发生率(93.55%)与联合组(90.32%)比较，差异无统计学意义(P > 0.05)。 结论 碘油联合Embosphere微球可使行TACE治疗的肝癌患者肿瘤缩小明显，远期生存率提高，值得临床推广。
[关键词] 肝癌；碘油；三丙烯微球； 经动脉化学栓塞
[中图分类号] R734 [文献标识码] A [文章编号] 1673-7210(2016)12(c)-0186-05
[Abstract] Objective To explore the influence of iodine oil combined with Embosphere microsphere on effect and prognosis of patients with liver cancer. Methods Sixty-two cases of patients with liver cancer treated in Hospital Affiliated to Nantong University from January 2010 to June 2012 were selected as the study objects， and were divided into control group and combination group according to choice of the materials. The control group were used with iodine oil in TACE treatment， and the combination group were used with iodine oil combined with Embosphere microsphere therapy. Tumor volume before and after treatment， and α-fetal protein (AFP)， liver function level before treatment and after treatment of four weeks were contrasted in the two groups， and survival rates after treatment of a year， three years and five years and incidence of adverse reactions after treatment were figured in the two groups. Results After treatment， tumor volume of the combination group was significantly smaller than that of the control group (P < 0.05). Serum AFP level significantly decreased when compared with that before treatment in the two groups(P < 0.05)， which in the combined group was lower than that in the control group (P < 0.05). There was no significant difference in Alanine aminotransferase (ALT) level between the two groups (P > 0.05). There were significant differences in levels of glutamic-oxalacetic transaminase (AST)， total bilirubin (TBIL) and albumin (ALB) between the combined group and the control group (P < 0.05). Average survival time was (47.21±6.32) months in the combination group， and median survival time was (56.42±6.36) months， while average survival time was (30.65±4.52) months in the control group， and median survival time (18.69±4.38) months. There were statistically significant in survival rates after treatment of a year， three years and five years in the two groups (P < 0.05). The incidence of adverse reactions in the control group was 93.55%， with no significant difference when compared with that of 90.32% in the combination group(P > 0.05). Conclusion Iodine oil combined with Embosphere microspheres can make tumor volume small in TACE treatment of patients with liver cancer， with high long-term survival rate. It is worthy of clinical promotion., 百拇医药(陆小华 朱小庆 储玉山)
[关键词] 肝癌；碘油；三丙烯微球； 经动脉化学栓塞
[中图分类号] R734 [文献标识码] A [文章编号] 1673-7210(2016)12(c)-0186-05
[Abstract] Objective To explore the influence of iodine oil combined with Embosphere microsphere on effect and prognosis of patients with liver cancer. Methods Sixty-two cases of patients with liver cancer treated in Hospital Affiliated to Nantong University from January 2010 to June 2012 were selected as the study objects， and were divided into control group and combination group according to choice of the materials. The control group were used with iodine oil in TACE treatment， and the combination group were used with iodine oil combined with Embosphere microsphere therapy. Tumor volume before and after treatment， and α-fetal protein (AFP)， liver function level before treatment and after treatment of four weeks were contrasted in the two groups， and survival rates after treatment of a year， three years and five years and incidence of adverse reactions after treatment were figured in the two groups. Results After treatment， tumor volume of the combination group was significantly smaller than that of the control group (P < 0.05). Serum AFP level significantly decreased when compared with that before treatment in the two groups(P < 0.05)， which in the combined group was lower than that in the control group (P < 0.05). There was no significant difference in Alanine aminotransferase (ALT) level between the two groups (P > 0.05). There were significant differences in levels of glutamic-oxalacetic transaminase (AST)， total bilirubin (TBIL) and albumin (ALB) between the combined group and the control group (P < 0.05). Average survival time was (47.21±6.32) months in the combination group， and median survival time was (56.42±6.36) months， while average survival time was (30.65±4.52) months in the control group， and median survival time (18.69±4.38) months. There were statistically significant in survival rates after treatment of a year， three years and five years in the two groups (P < 0.05). The incidence of adverse reactions in the control group was 93.55%， with no significant difference when compared with that of 90.32% in the combination group(P > 0.05). Conclusion Iodine oil combined with Embosphere microspheres can make tumor volume small in TACE treatment of patients with liver cancer， with high long-term survival rate. It is worthy of clinical promotion., 百拇医药(陆小华 朱小庆 储玉山)