[摘要] 雄激素性脱发是病理性脱发最主要的类型，易导致患者心理负担，影响日常生活，安全有效地治疗脱发是必要的。西药治疗具有作用机制明确、直接针对病因的特点，但口服给药存在疗程长、易反复及不良反应事件等问题，影响患者顺应性及治疗。本文阐述生长因子对毛发生长周期的影响，揭示雄激素性脱发的发病机制，讨论西药及其经皮给药系统的研究现状，为用于治疗雄激素性脱发的西药的开发及其局部给药制剂的设计提供一定思路。

    [关键词] 雄激素性脱发；经皮给药系统；机制

    [中图分类号] R758.71 [文献标识码] A [文章编号] 1673-7210(2017)02(b)-0043-05

    [Abstract] Androgenetic alopecia is the most common type of pathological hair loss. It is necessary to treat hair loss effectively and safely because of the psychological burden and influence in daily life of patients with androgenetic alopecia. The characteristics of western medicine are clear mechanism of action and directed against the pathogeny. However ......