急性ST段抬高型心肌梗死患者血清IL—37、TGF—β的表达及其意义(1)
[摘要] 目的 探讨急性ST段抬高型心肌梗死(STEMI)患者血清白细胞介素(IL)-37、转化生长因子β(TGF-β)的表达及其意义。 方法 选取2014年9月～2015年9月在民航总医院急诊科确诊且行经皮冠状动脉介入治疗(PCI)的STEMI患者40例作为实验组，同时选取40名常规体检者作为对照组。采用酶联免疫吸附测定(ELISA)法检测其外周血血清中IL-37、TGF-β的浓度。 结果 实验组患者血清IL-37浓度明显高于对照组(P = 0.02)，TGF-β浓度明显低于对照组，差异有统计学意义(P = 0.000)。实验组IL-37与TGF-β呈负相关(r = -0.79，P = 0.00)，对照组IL-37与TGF-β无明显相关性(r = 0.03，P = 0.86)。 结论 IL-37与TGF-β二者均参与STEMI的炎症过程。IL-37、TGF-β在STEMI炎性反应过程中具有负相关性，IL-37的抗炎作用发挥可能与TGF-β有关。
[关键词] 急性ST段抬高型心肌梗死；白细胞介素37；转化生长因子β
[中图分类号] R542.22 [文献标识码] A [文章编号] 1673-7210(2017)07(b)-0058-04
Expression and significance of serum IL-37， TGF-β in patients with acute ST-segment elevation myocardial infarction
ZHOU Yaguang WU Huihui WANG Ronghua YANG Kun LIU Ya′nan WANG Kun HE Jingli PENG Chunxia
Department of Emergency， Civil Aviation General Hospital， Beijing 100123， China
[Abstract] Objective To investigate the expression and significance of serum interleukin (IL)-37， transforming growth factor β (TGF-β) in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods Forty patients with STEMI diagnosed and taken percutaneous coronary intervention (PCI) in Department of Emergency， Civil Aviation General Hospital from September 2014 to September 2015 were selected as experimental group， and 40 normal regular healthy control were selected as control group. The concentration of serum IL-37， TGF-β in peripheral blood was detected by enzyme-linked immunosorbent assay (ELISA). Results The concentration of serum IL-37 in experimental group was significantly higher than that of control group (P = 0.02)， the concentration of TGF-β was significantly lower than that of control group， the difference was statistically significant (P = 0.000). The concentration of IL-37 was negatively correlated with TGF-β in experimental group (r = -0.79， P = 0.00)， while there was no obvious correlation between IL-37 and TGF-β in control group (r = 0.03， P = 0.86). Conclusion Both IL-37 and TGF-β are involved in the inflammatory process of STEMI. IL-37 and TGF-β has a negative correlation in the inflammatory process of STEMI. The anti-inflammatory effect of IL-37 may be related to TGF-β.
[Key words] Acute ST segment elevation myocardial infarction； Interleukin-37； Transforming growth factor β
急性ST段抬高型心肌梗死(STEMI)是一種常见的严重的心血管疾病，它是以动脉粥样斑块破裂、溃疡、糜烂或夹层，引起一支或多支冠状动脉血栓形成，导致心肌血流减少或远端血小板栓塞伴心肌坏死。冠状动脉粥样硬化形成及斑块的破裂是STEMI发病的主要机制，炎症参与了斑块破裂、血栓形成的整个过程，而抑炎因子对延缓冠状动脉粥样硬化进展及阻止心肌梗死的发生有重要作用[1]。2000年，Kumar等[2]发现了一种与经典白细胞介素(IL)-1家族具有共结构域的前体肽，2001年，Dunn等[3]发现这种前体肽属于IL-1家族，将其命名为IL-1F7。2010年Nold等[4]发现IL-1F7具有抗炎及抑制固有免疫的作用，遂将其命名为IL-37。有研究证实在冠状动脉粥样硬化斑块泡沫细胞中发现IL-37的存在，提示IL-37参与了冠状动脉粥样硬化过程[5]。转化生长因子β(TGF-β)是细胞生长增殖调节蛋白超家族的成员之一，具有多种生物功能。作为一种经典的抑炎因子，TGF-β在急性冠脉综合征中发挥保护作用[6-7]。最近有研究证实IL-37参与了急性冠脉综合征的炎症过程[8-9]，目前关于IL-37在STEMI患者中的水平及意义尚无定论，对于IL-37与TGF-β的关系尚无研究。本研究旨在探讨二者在STEMI中的水平、意义及二者之间的相关性。, http://www.100md.com(周亚光 吴惠惠 王荣花 杨昆 刘亚楠 王坤 何京丽 彭春霞)
[关键词] 急性ST段抬高型心肌梗死；白细胞介素37；转化生长因子β
[中图分类号] R542.22 [文献标识码] A [文章编号] 1673-7210(2017)07(b)-0058-04
Expression and significance of serum IL-37， TGF-β in patients with acute ST-segment elevation myocardial infarction
ZHOU Yaguang WU Huihui WANG Ronghua YANG Kun LIU Ya′nan WANG Kun HE Jingli PENG Chunxia
Department of Emergency， Civil Aviation General Hospital， Beijing 100123， China
[Abstract] Objective To investigate the expression and significance of serum interleukin (IL)-37， transforming growth factor β (TGF-β) in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods Forty patients with STEMI diagnosed and taken percutaneous coronary intervention (PCI) in Department of Emergency， Civil Aviation General Hospital from September 2014 to September 2015 were selected as experimental group， and 40 normal regular healthy control were selected as control group. The concentration of serum IL-37， TGF-β in peripheral blood was detected by enzyme-linked immunosorbent assay (ELISA). Results The concentration of serum IL-37 in experimental group was significantly higher than that of control group (P = 0.02)， the concentration of TGF-β was significantly lower than that of control group， the difference was statistically significant (P = 0.000). The concentration of IL-37 was negatively correlated with TGF-β in experimental group (r = -0.79， P = 0.00)， while there was no obvious correlation between IL-37 and TGF-β in control group (r = 0.03， P = 0.86). Conclusion Both IL-37 and TGF-β are involved in the inflammatory process of STEMI. IL-37 and TGF-β has a negative correlation in the inflammatory process of STEMI. The anti-inflammatory effect of IL-37 may be related to TGF-β.
[Key words] Acute ST segment elevation myocardial infarction； Interleukin-37； Transforming growth factor β
急性ST段抬高型心肌梗死(STEMI)是一種常见的严重的心血管疾病，它是以动脉粥样斑块破裂、溃疡、糜烂或夹层，引起一支或多支冠状动脉血栓形成，导致心肌血流减少或远端血小板栓塞伴心肌坏死。冠状动脉粥样硬化形成及斑块的破裂是STEMI发病的主要机制，炎症参与了斑块破裂、血栓形成的整个过程，而抑炎因子对延缓冠状动脉粥样硬化进展及阻止心肌梗死的发生有重要作用[1]。2000年，Kumar等[2]发现了一种与经典白细胞介素(IL)-1家族具有共结构域的前体肽，2001年，Dunn等[3]发现这种前体肽属于IL-1家族，将其命名为IL-1F7。2010年Nold等[4]发现IL-1F7具有抗炎及抑制固有免疫的作用，遂将其命名为IL-37。有研究证实在冠状动脉粥样硬化斑块泡沫细胞中发现IL-37的存在，提示IL-37参与了冠状动脉粥样硬化过程[5]。转化生长因子β(TGF-β)是细胞生长增殖调节蛋白超家族的成员之一，具有多种生物功能。作为一种经典的抑炎因子，TGF-β在急性冠脉综合征中发挥保护作用[6-7]。最近有研究证实IL-37参与了急性冠脉综合征的炎症过程[8-9]，目前关于IL-37在STEMI患者中的水平及意义尚无定论，对于IL-37与TGF-β的关系尚无研究。本研究旨在探讨二者在STEMI中的水平、意义及二者之间的相关性。, http://www.100md.com(周亚光 吴惠惠 王荣花 杨昆 刘亚楠 王坤 何京丽 彭春霞)