[摘要] 多形性胶质母细胞瘤(GBM)是最致命的一种异质性脑肿瘤，GBM患者存活时间为8～15个月。GBM由复杂的信号通路驱动，对于GBM的治疗一直被认为是最具挑战性的，GBM的标准治疗包括手术、放射治疗、化疗和联合治疗。本文综述了GBM的肿瘤间和肿瘤内异质性、最新的化疗药物及作用机制，重点介绍了一些天然合成和新型抗胶质瘤药物，也是当今研究人员的主要研究热点。

    [关键词] 多形性胶质母细胞瘤；异质性；联合治疗；化疗药物

    [中图分类号] R739.41 [文献标识码] A [文章编号] 1673-7210(2017)12(b)-0029-04

    [Abstract] Glioblastoma multiforme (GBM) is the most deadly type of heterogeneous brain tumor. The survival time of patients with pleomorphic glioblastoma is 8 to 15 months. GBM is driven by complex signaling pathways， the treatment of which has always been considered as the most challenging ......