综上所述，孕期一定剂量PM2.5暴露使子代鼠大脑皮层炎症因子表达改变，HMGB1/NF-κB通路可能起关键作用。孕期PM2.5暴露影响子代脑发育是多机制调节的复杂过程，了解其对子代脑发育的影响对提高空气污染预防意识及尽早建立孕妇和胎儿特异监测指标有重要意义。

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