右美托咪定联合利多卡因静脉输注对腹腔镜全子宫切除术患者氧化应激水平及炎性反应的影响(1)
[摘要] 目的 探討右美托咪定联合利多卡因对腹腔镜全子宫切除术患者氧化应激和炎性反应的影响。 方法 选取2014年9月～2017年10月宜宾市第一人民医院妇科全麻行腹腔镜全子宫切除术患者120例为研究对象，根据随机数字表法将其分为A、B、C组和对照组，各30例。A组予以右美托咪定联合利多卡因静脉泵注，B组予以右美托咪定静脉泵注，C组予以利多卡因静脉泵注，对照组予以生理盐水静脉泵注。于给药前(T1)、手术结束时(T2)、术后2 h(T3)和术后24 h (T4)对氧化应激指标[过氧化氢(H2O2)、丙二醛(MDA)、总抗氧化态(TAS)]及炎性因子[白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]进行监测。比较四组术后不良反应发生率。 结果 在T2、T3、T4时，血清H2O2、MDA水平A组B组>C组>对照组，组间比较差异有差异统计学意义(P < 0.05)；血清IL-6、TNF-α水平A组 group B> group C> control group， the difference between groups was statistically significant (P < 0.05). The incidence of nausea and vomiting in group A was lower than that in group B and control group， the difference was statistically significant (P < 0.05). The incidence of somnolence and bradycardia in group A and B was higher than that in group C and control group， the difference was statistically significant (P < 0.05). Conclusion Dexmedetomidine combined with Lidocaine can alleviate the oxidative stress response and inflammatory response in patients with laparoscopic total hysterectomy. However， the incidence of somnolence and bradycardia increased after operation., http://www.100md.com(张努 徐连生)