帕金森病及快动眼期睡眠行为障碍患者血浆尿酸水平的关系(1)
[摘要] 目的 探讨帕金森病(PD)及快动眼期睡眠行为障碍(RBD)患者血浆尿酸水平的关系。 方法 收集2016年3月～2017年3月就诊于首都医科大学宣武医院的特发性RBD(iRBD)患者39例(iRBD组)、PD患者43例(PD组)、健康对照者128名(健康对照组)。iRBD患者均经临床评估和多导睡眠图确诊。检测受试者血浆尿酸水平。采用双因素方差分析研究iRBD和PD患者尿酸水平的异常情况。 结果 iRBD组血尿酸值[(346.5±38.3)mmol/L]明显高于PD组[(236.5±49.8)mmol/L]及健康对照组[(331.0±39.8)mmol/L]，差异均有高度统计学意义(P < 0.01)；PD组与健康对照组比较，差异无统计学意义(P > 0.05)。 结论 PD患者尿酸水平低于健康人群和iRBD组，因而可能是PD的一个生物学标志。
[关键词] 帕金森病；快动眼期睡眠行为障碍；尿酸
[中图分类号] R745 [文献标识码] A [文章编号] 1673-7210(2018)05(b)-0086-03
The relationships in plasma uric acid levels between patients with Parkinson disease and rapid-eye-movement sleep behavior disorder
LIU Jianghong1* LI Kai2* LI Ning1 DING Yan1 ZHANG Lichun3 ZHAI Yi1 WANG Yuping1 ZHAN Shuqin1
1.Department of Neurology， Xuanwu Hospital， Capital Medical University， Beijing 100053， China； 2.Department of Neurology， Beijing Hospital， Beijing 100730， China； 3.Clinical Laboratory， Xuanwu Hospital， Capital Medical University， Beijing 100053， China
[Abstract] Objective To investigate the relationships in plasma uric acid levels between patients with Parkinson disease (PD) and rapid-eye-movement sleep behavior disorder (RBD). Methods Thirty-nine patients with idiopathic RBD (iRBD group)， 43 patients with PD (PD group) and 128 healthy controls (healthy control group) were collected from Xuanwu Hospital， Capital Medical University from March 2016 to March 2017. All patients with iRBD were confirmed by clinical assessment and polysomnography. Subjects' plasma uric acid levels were measured. Two-way analysis of variance was used to examine abnormalities in uric acid levels in patients with iRBD and PD. Results The levels of serum uric acid in the iRBD group [(346.5±38.3) mmol/L] were significantly higher than that of the PD group [(236.5±49.8) mmol/L] and the healthy control group [(331.0±39.8) mmol/L]， the differences were all statistically significant (P < 0.01). But there was no significant difference between the PD group and the healthy control group (P > 0.05). Conclusion Uric acid levels in PD patients are lower than those in healthy subjects and RBD patients， suggesting that low uric acid level may be a biological marker of PD.
[Key words] Parkinson disease； Rapid-eye-movement sleep behavior disorder； Uric acid
帕金森病(PD)是一種以黑质纹状体多巴胺能神经元变性引起的运动症状为特征的神经退行性疾病。目前PD的确切病因仍不清楚，多项研究[1-3]提示PD患者血尿酸水平减低，可能是PD的一个生物学标志。快动眼期睡眠行为障碍(rapid-eye-movement sleep behavior disorder，RBD)是以快动眼睡眠期间伴随梦境和肢体活动为特征的睡眠疾病，约60%的患者起病前没有明确诱因即特发性RBD(idiopathic RBD，iRBD)，更重要的是，iRBD还存在α-突触核蛋白的病理学改变，相当一部分iRBD患者随访多年后会转化为PD患者[4]。国外一项研究初步显示[5]，iRBD患者血尿酸水平高于伴PD的RBD患者，提示高尿酸水平可能是防止iRBD向PD发展的重要因素，然而该研究样本量小，且缺少健康对照者，无法评价其iRBD及伴PD的RBD患者血尿酸水平与正常人群相比是否异常。因而，本研究收集iRBD和PD患者、健康对照，探讨三组间尿酸水平的差异，为阐述尿酸与PD发生的关联，指导其防治提供数据支持。, http://www.100md.com(刘江红 李凯 李宁 丁岩 张丽春 翟怡 王玉平 詹淑琴)
[关键词] 帕金森病；快动眼期睡眠行为障碍；尿酸
[中图分类号] R745 [文献标识码] A [文章编号] 1673-7210(2018)05(b)-0086-03
The relationships in plasma uric acid levels between patients with Parkinson disease and rapid-eye-movement sleep behavior disorder
LIU Jianghong1* LI Kai2* LI Ning1 DING Yan1 ZHANG Lichun3 ZHAI Yi1 WANG Yuping1 ZHAN Shuqin1
1.Department of Neurology， Xuanwu Hospital， Capital Medical University， Beijing 100053， China； 2.Department of Neurology， Beijing Hospital， Beijing 100730， China； 3.Clinical Laboratory， Xuanwu Hospital， Capital Medical University， Beijing 100053， China
[Abstract] Objective To investigate the relationships in plasma uric acid levels between patients with Parkinson disease (PD) and rapid-eye-movement sleep behavior disorder (RBD). Methods Thirty-nine patients with idiopathic RBD (iRBD group)， 43 patients with PD (PD group) and 128 healthy controls (healthy control group) were collected from Xuanwu Hospital， Capital Medical University from March 2016 to March 2017. All patients with iRBD were confirmed by clinical assessment and polysomnography. Subjects' plasma uric acid levels were measured. Two-way analysis of variance was used to examine abnormalities in uric acid levels in patients with iRBD and PD. Results The levels of serum uric acid in the iRBD group [(346.5±38.3) mmol/L] were significantly higher than that of the PD group [(236.5±49.8) mmol/L] and the healthy control group [(331.0±39.8) mmol/L]， the differences were all statistically significant (P < 0.01). But there was no significant difference between the PD group and the healthy control group (P > 0.05). Conclusion Uric acid levels in PD patients are lower than those in healthy subjects and RBD patients， suggesting that low uric acid level may be a biological marker of PD.
[Key words] Parkinson disease； Rapid-eye-movement sleep behavior disorder； Uric acid
帕金森病(PD)是一種以黑质纹状体多巴胺能神经元变性引起的运动症状为特征的神经退行性疾病。目前PD的确切病因仍不清楚，多项研究[1-3]提示PD患者血尿酸水平减低，可能是PD的一个生物学标志。快动眼期睡眠行为障碍(rapid-eye-movement sleep behavior disorder，RBD)是以快动眼睡眠期间伴随梦境和肢体活动为特征的睡眠疾病，约60%的患者起病前没有明确诱因即特发性RBD(idiopathic RBD，iRBD)，更重要的是，iRBD还存在α-突触核蛋白的病理学改变，相当一部分iRBD患者随访多年后会转化为PD患者[4]。国外一项研究初步显示[5]，iRBD患者血尿酸水平高于伴PD的RBD患者，提示高尿酸水平可能是防止iRBD向PD发展的重要因素，然而该研究样本量小，且缺少健康对照者，无法评价其iRBD及伴PD的RBD患者血尿酸水平与正常人群相比是否异常。因而，本研究收集iRBD和PD患者、健康对照，探讨三组间尿酸水平的差异，为阐述尿酸与PD发生的关联，指导其防治提供数据支持。, http://www.100md.com(刘江红 李凯 李宁 丁岩 张丽春 翟怡 王玉平 詹淑琴)
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