[摘要] 动脉粥样硬化(AS)是各种心脑血管疾病的病理基础，严重威胁着人类的健康，近年来炎症学说受到了越来越多学者的重视，从抗炎及免疫调节角度探讨抗AS是一种新思路，在炎症演变过程中，有多条信号通路参与其中，深入研究信号通路，有望成为动脉粥样硬化药物研究干预靶点。本文从分子生物学水平总结前瞻性的基础研究进展，以期给AS及其相关疾病的治疗带来启发。

    [关键词] 动脉粥样硬化；心脑血管疾病；炎症学说；信号通路

    [中图分类号] R543.12 [文献标识码] A [文章编号] 1673-7210(2018)09(c)-0030-05

    [Abstract] Atherosclerosis (AS) is the pathological basis of cardiovascular disease， which is a serious threat to human health. In recent years， more and more scholars pay attention to the theory of inflammation. It is a new idea to treat AS from the point of view with antiinflammation and immunoregulation. There are multiple signal transduction pathways involved in the course of inflammation progress. The signaling pathway is studied deeply that is expected to become a target for intervention of atherosclerosis drugs. This article summerizes the prospective basic experimental from cellular and molecular level ......