丁苯酞治疗急性脑梗死合并轻度认知功能障碍的效果(1)
[摘要] 目的 探讨丁苯酞治疗急性脑梗死合并轻度认知功能障碍的效果。 方法 选取2017年6月～2018年3月在河北省衡水市冀州区医院内二科住院治疗的120例急性脑梗死合并轻度认知功能障碍患者，采用随机数字表法将所有患者分为观察组和对照组，每组各60例。对照组采取常规药物治疗，观察组在对照组的基础上联合丁苯酞治疗，两组均连续治疗14 d。治疗后比较两组简易精神状态检查量表(MMSE)各项评分及临床疗效。结果 两组患者治疗前MMSE各项评分比较，差异无统计学意义(P > 0.05)。治疗后观察组患者的时间向力、地点向力、即刻记忆、注意力及计算力、延迟记忆、语言、视空间评分均明显高于对照组，差异有统计学意义(P < 0.05)。治疗后，观察组患者治疗后的临床总有效率明显高于对照组，差异有统计学意义(P < 0.05)。 结论 丁苯酞治疗急性脑梗死合并轻度认知功能障碍效果确切，可以显著改善患者的认知功能障碍，值得临床广泛推广和应用。
[关键词] 急性脑梗死;轻度认知功能障碍;丁苯酞;简易精神状态检查量表
[中图分类号] R749.13 [文献标识码] A [文章编号] 1673-7210(2018)12(b)-0078-04
[Abstract] Objective To investigate the effect of butylphthalide on acute cerebral infarction complicated with mild cognitive dysfunction. Methods From June 2017 to March 2018， 120 patients with acute cerebral infarction combined with mild cognitive impairment who were hospitalized in the Second Department of Internal Medicine of Jizhou District Hospital in Hengshui City， Hebei Province were selected. According to the random number table， all patients were divided into observation group and control group， each group of 60 cases. The control group received the routine drug treatment， the observation group was treated with Batylphthdide on the basis of ontrol group， two groups received continuous treatment of 14 d. After treatment， the scores of the mini-mental state examination (MMSE) and the clinical efficacy of the two groups were compared. Results There was no significant difference in MMSE scores before treatment between the two groups (P > 0.05). The time， place， instant memory， attention and computational power， delayed memory， language and visuospatial scores of the observation group were significantly higher than those of the control group， with statistically significant differences (P < 0.05). After treatment， the total clinical efficacy of the observation group was significantly higher than that of the control group， with statistically significant difference (P < 0.05). Conclusion The efficacy of Butylphthalide in the treatment of acute cerebral infarction complicated with mild cognitive impainnent is definite， which can significantly improve the cognitive dysfunction of patients and is worthy of wide clinical application.
[Key words] Acute cerebral infarction; Mild cognitive impairment; Butylphthalide; Mini-mental state examination
腦梗死是神经内科的常见病、多发病，近年来随着人口老龄化的加剧，其发病率逐年升高。脑梗死患者由于血管堵塞致脑组织出现血供障碍，局部脑组织缺血缺氧，导致患者出现神经功能缺损及认知功能障碍[1]。轻度认知功能障碍主要临床表现为思维、计算能力下降，记忆力、行为能力受损等，严重影响患者的生活质量，若治疗不及时，可能逐渐恶化为血管性痴呆[2-3]。, 百拇医药(王艳茹)
[关键词] 急性脑梗死;轻度认知功能障碍;丁苯酞;简易精神状态检查量表
[中图分类号] R749.13 [文献标识码] A [文章编号] 1673-7210(2018)12(b)-0078-04
[Abstract] Objective To investigate the effect of butylphthalide on acute cerebral infarction complicated with mild cognitive dysfunction. Methods From June 2017 to March 2018， 120 patients with acute cerebral infarction combined with mild cognitive impairment who were hospitalized in the Second Department of Internal Medicine of Jizhou District Hospital in Hengshui City， Hebei Province were selected. According to the random number table， all patients were divided into observation group and control group， each group of 60 cases. The control group received the routine drug treatment， the observation group was treated with Batylphthdide on the basis of ontrol group， two groups received continuous treatment of 14 d. After treatment， the scores of the mini-mental state examination (MMSE) and the clinical efficacy of the two groups were compared. Results There was no significant difference in MMSE scores before treatment between the two groups (P > 0.05). The time， place， instant memory， attention and computational power， delayed memory， language and visuospatial scores of the observation group were significantly higher than those of the control group， with statistically significant differences (P < 0.05). After treatment， the total clinical efficacy of the observation group was significantly higher than that of the control group， with statistically significant difference (P < 0.05). Conclusion The efficacy of Butylphthalide in the treatment of acute cerebral infarction complicated with mild cognitive impainnent is definite， which can significantly improve the cognitive dysfunction of patients and is worthy of wide clinical application.
[Key words] Acute cerebral infarction; Mild cognitive impairment; Butylphthalide; Mini-mental state examination
腦梗死是神经内科的常见病、多发病，近年来随着人口老龄化的加剧，其发病率逐年升高。脑梗死患者由于血管堵塞致脑组织出现血供障碍，局部脑组织缺血缺氧，导致患者出现神经功能缺损及认知功能障碍[1]。轻度认知功能障碍主要临床表现为思维、计算能力下降，记忆力、行为能力受损等，严重影响患者的生活质量，若治疗不及时，可能逐渐恶化为血管性痴呆[2-3]。, 百拇医药(王艳茹)