微生态制剂双歧杆菌三联活菌胶囊辅助治疗老年性肺炎的临床效果(1)
[摘要] 目的 探討微生态制剂双歧杆菌三联活菌胶囊辅助治疗老年性肺炎的临床效果。 方法 回顾性分析2016年9月～2017年10月河北省涿州市医院呼吸内科收治的160例老年肺炎患者临床资料，仅采取常规抗感染治疗者纳入对照组(80例)，在其基础上予以微生态制剂辅助治疗者纳入观察组(80例)。比较治疗前及治疗2周后两组血清生化指标[降钙素原(PCT)、二胺氧化酶(DAO)、内毒素]、细胞免疫指标[CD3+、CD4+/CD8+、自然杀伤(NK)细胞]变化，分析治疗2周后两组临床症状/体征缓解情况及药物不良反应发生情况差异。 结果 治疗2周后，两组血清PCT、DAO、内毒素水平均较治疗前有显著下降，且观察组明显低于同一时间对照组(P < 0.05);两组CD3+水平均较治疗前无明显变化，且组间比较差异无统计学意义(P > 0.05);两组CD4+/CD8+、NK细胞水平则均较治疗前有显著提升，且观察组明显高于同一时间对照组(P < 0.05)。观察组各项临床症状/体征缓解时间均明显少于对照组(P < 0.05)。治疗2周内，观察组腹泻、恶心呕吐、腹胀发生率均明显低于对照组(P < 0.05);而两组头晕头痛、瘙痒皮疹发生率比较，差异无统计学意义(P > 0.05)。 结论 微生态制剂应用于老年性肺炎可有效增强抗感染治疗效果，减少抗生素引起的胃肠道不良反应，对患者预后康复有利。
[关键词] 微生态制剂;双歧杆菌三联活菌胶囊;老年;肺炎
[中图分类号] R563.1 [文献标识码] A [文章编号] 1673-7210(2019)02(c)-0126-04
[Abstract] Objective To explore the clinical effects of microecologics Bifid Triple Viable Capsules in the adjuvant treatment of senile pneumonia. Methods The clinical data of 160 senile patients with pneumonia in Department of Respiratory Medicine of Zhuozhou City Hospital from September 2016 to October 2017 were retrospectively analyzed. Patients who were only given conventional anti-infective treatment were included in control group (80 cases). On this basis， patients who were given microecologics adjuvant therapy were included in observation group (80 cases). Serum biochemical parameters [procalcitonin (PCT)， diamine oxidase (DAO)， endotoxin] and cellular immune markers [CD3+， CD4+/CD8+， natural killer (NK) cell] were compared between the two groups before treatment and after 2 weeks of treatment. And the remission of clinical symptoms/signs and occurrence of adverse drug reactions were analyzed in the two groups after 2 weeks of treatment. Results After 2 weeks of treatment， the serum levels of PCT， DAO and endotoxin were significantly lower than those before treatment， and the levels in observation group were significantly lower than those in control group at the same time (P < 0.05). The CD3+ levels in the two groups were not significantly different from those before treatment， and there was no statistically significant difference between the two groups (P > 0.05). The levels of CD4+/CD8+ and NK cell in the two groups were significantly higher than those before treatment， and the levels in observation group were significantly higher than those in control group at the same time (P < 0.05). The remission times of clinical symptoms/signs in observation group were significantly lower than those in control group (P < 0.05). Within 2 weeks of treatment， the incidence rates of diarrhea， nausea and vomiting and abdominal distension in observation group were significantly lower than those in control group (P < 0.05). There were no significant differences in the incidence rates of dizziness headache and itching rash between the two groups (P > 0.05). Conclusion Microecologics for senile pneumonia can effectively enhance the anti-infective treatment effects， and reduce the gastrointestinal adverse reactions caused by antibiotics， and it is beneficial to the prognosis and rehabilitation of patients., 百拇医药(郭青春 张杰根 张硕 史娜 杨艳)
[关键词] 微生态制剂;双歧杆菌三联活菌胶囊;老年;肺炎
[中图分类号] R563.1 [文献标识码] A [文章编号] 1673-7210(2019)02(c)-0126-04
[Abstract] Objective To explore the clinical effects of microecologics Bifid Triple Viable Capsules in the adjuvant treatment of senile pneumonia. Methods The clinical data of 160 senile patients with pneumonia in Department of Respiratory Medicine of Zhuozhou City Hospital from September 2016 to October 2017 were retrospectively analyzed. Patients who were only given conventional anti-infective treatment were included in control group (80 cases). On this basis， patients who were given microecologics adjuvant therapy were included in observation group (80 cases). Serum biochemical parameters [procalcitonin (PCT)， diamine oxidase (DAO)， endotoxin] and cellular immune markers [CD3+， CD4+/CD8+， natural killer (NK) cell] were compared between the two groups before treatment and after 2 weeks of treatment. And the remission of clinical symptoms/signs and occurrence of adverse drug reactions were analyzed in the two groups after 2 weeks of treatment. Results After 2 weeks of treatment， the serum levels of PCT， DAO and endotoxin were significantly lower than those before treatment， and the levels in observation group were significantly lower than those in control group at the same time (P < 0.05). The CD3+ levels in the two groups were not significantly different from those before treatment， and there was no statistically significant difference between the two groups (P > 0.05). The levels of CD4+/CD8+ and NK cell in the two groups were significantly higher than those before treatment， and the levels in observation group were significantly higher than those in control group at the same time (P < 0.05). The remission times of clinical symptoms/signs in observation group were significantly lower than those in control group (P < 0.05). Within 2 weeks of treatment， the incidence rates of diarrhea， nausea and vomiting and abdominal distension in observation group were significantly lower than those in control group (P < 0.05). There were no significant differences in the incidence rates of dizziness headache and itching rash between the two groups (P > 0.05). Conclusion Microecologics for senile pneumonia can effectively enhance the anti-infective treatment effects， and reduce the gastrointestinal adverse reactions caused by antibiotics， and it is beneficial to the prognosis and rehabilitation of patients., 百拇医药(郭青春 张杰根 张硕 史娜 杨艳)