止痛如神汤对肛瘘术后伤口愈合及疼痛程度的影响(1)
[摘要] 目的 探讨止痛如神汤对肛瘘术后伤口愈合及疼痛程度的影响。 方法 选取贵阳中医学院第一附属医院2015年12月～2018年6月肛瘘术后患者60例，随机数字表法分为对照组(n = 30)与研究组(n = 30)。对照组采用地奥司明及高锰酸钾坐浴，研究组在对照组基础上采用止痛如神汤，两组均治疗3周。统计比较两组临床疗效、创面愈合时间及便血消失时间，治疗前后血清表皮生长因子(EGF)与纖维连接蛋白(FN)水平、创面纵径及创面面积、症状(疼痛程度、肉芽形态、创面渗液)积分。 结果 研究组总有效率高于对照组(P < 0.05)。研究组创面愈合时间及便血消失时间均短于对照组(P < 0.01)。两组治疗后血清EGF与FN水平均高于本组治疗前(P < 0.01)，且研究组高于对照组(P < 0.05)。治疗后两组创面纵径及创面面积较本组治疗前缩小(P < 0.01)，且研究组小于对照组(P < 0.01)。治疗后两组疼痛程度、肉芽形态、创面渗液分值较本组治疗前降低(P < 0.01)，且研究组低于对照组(P < 0.01)。 结论 采取止痛如神汤治疗肛瘘术后患者，可有效缩短创面愈合及便血消失时间，促使创面消失，减轻患者疼痛感，缓解患者临床症状，增加血清EGF与FN水平，提高疾病治疗效果。
[关键词] 止痛如神汤;肛瘘;伤口愈合;疼痛程度;表皮生长因子;纤维连接蛋白
[中图分类号] R266 [文献标识码] A [文章编号] 1673-7210(2019)02(c)-0137-05
[Abstract] Objective To investigate the effect of Zhitong Rushen Decoction on wound healing and pain degree after anal fistula operation. Methods Sixty patients with anal fistula from December 2015 to June 2018 in the First Affiliated Hospital to Guiyang College of Traditional Chinese Medicine were selected. By the random number table method all the patients were divided into control group (n = 30) and study group (n = 30). The control group was treated with Diosmin and Potassium Permanganate. The study group was treated with Zhitong Rushen Decoction on the basis of the control group， and the two groups were treated for 3 weeks. The clinical efficacy， wound healing time and disappearance time of blood in the stool， serum epidermal growth factor (EGF) and fibronectin (FN) levels， wound longitudinal diameter and wound area， symptoms (pain level， granulation morphology)， wound surface exudate) integral were measured and comparedy between the two groups. Results The total effective rate of the study group was higher than that of the control group (P < 0.05). The healing time of the wound in the study group and the disappearance time of blood in stool in the study group were shorter than those in the control group (P < 0.05). After treatment， serum EGF and FN levels in the two groups were higher than those before treatment (P < 0.01)， and those in the study group were higher than those in the control group (P < 0.05). After treatment， the longitudinal diameter and wound area of the two groups were smaller than those before treatment (P < 0.01)， and those in the study group were smaller than those in the control group (P < 0.01). After treatment， scores of the pain level， granulation morphology and wound exudate in the two groups were lower than those before treatment (P < 0.01)， and those in the study group were lower than those in the control group (P < 0.01). Conclusion The treatment of anal fistula with Zhitong Rushen Decoction can effectively shorten the healing time of wound healing and blood in the stool， promote the disappearance of wounds， reduce the pain of patients， relieve the clinical symptoms， increase the levels of serum EGF and FN， and improve the therapeutic effect of the disease., 百拇医药(苗大兴 赖蕾 苗晨)
[关键词] 止痛如神汤;肛瘘;伤口愈合;疼痛程度;表皮生长因子;纤维连接蛋白
[中图分类号] R266 [文献标识码] A [文章编号] 1673-7210(2019)02(c)-0137-05
[Abstract] Objective To investigate the effect of Zhitong Rushen Decoction on wound healing and pain degree after anal fistula operation. Methods Sixty patients with anal fistula from December 2015 to June 2018 in the First Affiliated Hospital to Guiyang College of Traditional Chinese Medicine were selected. By the random number table method all the patients were divided into control group (n = 30) and study group (n = 30). The control group was treated with Diosmin and Potassium Permanganate. The study group was treated with Zhitong Rushen Decoction on the basis of the control group， and the two groups were treated for 3 weeks. The clinical efficacy， wound healing time and disappearance time of blood in the stool， serum epidermal growth factor (EGF) and fibronectin (FN) levels， wound longitudinal diameter and wound area， symptoms (pain level， granulation morphology)， wound surface exudate) integral were measured and comparedy between the two groups. Results The total effective rate of the study group was higher than that of the control group (P < 0.05). The healing time of the wound in the study group and the disappearance time of blood in stool in the study group were shorter than those in the control group (P < 0.05). After treatment， serum EGF and FN levels in the two groups were higher than those before treatment (P < 0.01)， and those in the study group were higher than those in the control group (P < 0.05). After treatment， the longitudinal diameter and wound area of the two groups were smaller than those before treatment (P < 0.01)， and those in the study group were smaller than those in the control group (P < 0.01). After treatment， scores of the pain level， granulation morphology and wound exudate in the two groups were lower than those before treatment (P < 0.01)， and those in the study group were lower than those in the control group (P < 0.01). Conclusion The treatment of anal fistula with Zhitong Rushen Decoction can effectively shorten the healing time of wound healing and blood in the stool， promote the disappearance of wounds， reduce the pain of patients， relieve the clinical symptoms， increase the levels of serum EGF and FN， and improve the therapeutic effect of the disease., 百拇医药(苗大兴 赖蕾 苗晨)