[摘要] 经典Ph染色体阴性的骨髓增殖性肿瘤(MPN)是造血干细胞克隆性疾病。血栓是影响MPN患者生存的最主要并发症。MPN血栓形成机制可能与以下多种机制相关，包括血细胞数量增多及活化、内皮细胞异常、凝血系统激活、微颗粒与炎性细胞因子增多、JAK2V617F基因突变等。本文对MPN并发血栓形成机制的研究进展进行了综述，阐明这些机制有助于临床寻找新的预测血栓的生物学标志，为MPN患者血栓预防和治疗提供参考。

    [关键词] 血栓形成;骨髓增殖性肿瘤;细胞活化;基因突变

    [中图分类号] R733.3 [文献标识码] A [文章编号] 1673-7210(2019)08(c)-0032-04

    [Abstract] Classic negative Ph chromosome of myeloproliferative neoplasms (MPN) is a clonal disease of hematopoietic stem cells. Thrombus is the most important complication that affects the survival of MPN patients. The mechanism of thrombosis of MPN may be related to a variety of mechanisms including increased blood cell counts and activation ......