妊娠期糖尿病对新生儿脐带血血气分析的影响(1)
[摘要] 目的 探討妊娠期糖尿病(GDM)对新生儿脐带血血气分析的影响。 方法 随机抽取佛山市妇幼保健院2017年1月～2018年8月的单胎GDM孕妇2913例，非GDM孕妇3216例，采用血气电解质分析仪检测新生儿脐带血各项指标，进行组间比较，并对GDM组血气结果进行亚组分析，包括口服葡萄糖耐量实验(OGTT)检测不同时点血糖异常亚组与不同分娩方式亚组。 结果 GDM组与非GDM组的细胞外液碱剩余(BEecf)、血液碱剩余(BEb)、标准碳酸氢根浓度(SBC)、二氧化碳总量(TCO2)、二氧化碳分压(PCO2)及钠(Na+)含量比较，差异有统计学意义(P < 0.05)。OGTT不同时点血糖异常的GDM新生儿脐动脉血中BEecf、BEb、TCO2、肺泡动脉氧分压(A-aDO2)、Na+含量比较，差异有统计学意义(P < 0.05)。GDM剖宫产组与GDM阴道分娩组除氧分压(PO2)、血氧饱和度(SaO2)、Na+含量外，其余检测指标比较差异均有统计学意义(P < 0.05)。 结论 在GDM孕妇血糖控制理想的情况下，BEb、TCO2及SBC出现变化，但还不足以影响脐血的pH值，且对PO2及SaO2无太大影响。
[关键词] 妊娠期糖尿病;血气分析;妊娠结局;新生儿结局
[中图分类号] R714.14 [文献标识码] A [文章编号] 1673-7210(2019)10(c)-0101-05
Effect of gestational diabetes mellitus on blood gas analysis of neonatal umbilical cord
SUO Dongmei ZHOU Zixing LIU Juan GUO Qileng LI Weiling
Department of Obstetrics， Foshan Women and Children′s Hospital Affiliated to Southern Medical University， Guangdong Province， Foshan 528000， China
[Abstract] Objective To investigate the effect of gestational diabetes mellitus (GDM) on blood gas analysis in neonates. Methods A total of 2913 GDM and 3216 non-GDM women with single pregnancy in Foshan Women and Children′s Hospital from January 2017 to August 2018 were randomly sampled and collected. All indexes of neonatal umbilical cord blood were tested by blood gas electrolyte analyzer， and further analyzed between groups and subgroups， including subgroups of blood glucose abnormality at different time point of oral glucose tolerance test (OGTT) and subgroups of delivery mode. Results The results of base excess extracellular fluid (BEecf)， BEblood (BEb)， standard bicarbonate concentration (SBC)， total carbon dioxide (TCO2)， partial pressure of carbon dioxide (PCO2) and sodium (Na+) between GDM group and non-GDM group were compared， and the differences were tstatistically significant (P < 0.05). There were significant difference in BEecf， BEb， TCO2， partial alveolar arterial oxygen pressure (A-aDO2) and Na+ among GDM neonates with abnormal blood glucose at different time points of OGTT (P < 0.05). In addition to oxygen partial pressure (PO2)， oxyhemoglobin saturation (SaO2) and Na+ between GDM cesarean section group and GDM vaginal delivery group， there were significant differences in other detection indexes (P < 0.05). Conclusion Under the ideal condition of blood glucose control in GDM pregnant women， BEb， TCO2 and SBC changed， but not enough to affect the pH value of umbilical cord blood， and had no significant effect on PO2 and SaO2., 百拇医药(索冬梅 周姿杏 刘娟 郭绮棱 李伟玲)
[关键词] 妊娠期糖尿病;血气分析;妊娠结局;新生儿结局
[中图分类号] R714.14 [文献标识码] A [文章编号] 1673-7210(2019)10(c)-0101-05
Effect of gestational diabetes mellitus on blood gas analysis of neonatal umbilical cord
SUO Dongmei ZHOU Zixing LIU Juan GUO Qileng LI Weiling
Department of Obstetrics， Foshan Women and Children′s Hospital Affiliated to Southern Medical University， Guangdong Province， Foshan 528000， China
[Abstract] Objective To investigate the effect of gestational diabetes mellitus (GDM) on blood gas analysis in neonates. Methods A total of 2913 GDM and 3216 non-GDM women with single pregnancy in Foshan Women and Children′s Hospital from January 2017 to August 2018 were randomly sampled and collected. All indexes of neonatal umbilical cord blood were tested by blood gas electrolyte analyzer， and further analyzed between groups and subgroups， including subgroups of blood glucose abnormality at different time point of oral glucose tolerance test (OGTT) and subgroups of delivery mode. Results The results of base excess extracellular fluid (BEecf)， BEblood (BEb)， standard bicarbonate concentration (SBC)， total carbon dioxide (TCO2)， partial pressure of carbon dioxide (PCO2) and sodium (Na+) between GDM group and non-GDM group were compared， and the differences were tstatistically significant (P < 0.05). There were significant difference in BEecf， BEb， TCO2， partial alveolar arterial oxygen pressure (A-aDO2) and Na+ among GDM neonates with abnormal blood glucose at different time points of OGTT (P < 0.05). In addition to oxygen partial pressure (PO2)， oxyhemoglobin saturation (SaO2) and Na+ between GDM cesarean section group and GDM vaginal delivery group， there were significant differences in other detection indexes (P < 0.05). Conclusion Under the ideal condition of blood glucose control in GDM pregnant women， BEb， TCO2 and SBC changed， but not enough to affect the pH value of umbilical cord blood， and had no significant effect on PO2 and SaO2., 百拇医药(索冬梅 周姿杏 刘娟 郭绮棱 李伟玲)