人工智能在新药研发领域中的应用(5)
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[24] Steindl TM，Schuster D，Laggner C，et al. Parallel screening：a novel concept in pharmacophore modeling and virtual screening [J]. J Cheminform，2006，46(5)：2146-2157.
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[27] 金小桃.健康医疗大数据[M].北京：人民卫生出版社，2018：159-160.
(收稿日期：2019-05-07 本文编辑：李亚聪), 百拇医药(孙雅婧 李春漾 曾筱茜)
[20] Shin M，Jang D，Nam H，et al. Predicting the absorption potential of chemical compounds through a deep learning approach [J]. IEEE/ACM Trans Comput Biol Bioinform，2018，15(2)：432-440.
[21] Keiser MJ，Roth BL，Armbruster BN，et al. Relating protein pharmacology by ligand chemistry [J]. Nat Biotechnol，2007，25(2)：197-206.
[22] Pogodin PV，Lagunin AA，Filimonov DA，et al. PASS targets：ligand-based multi-target computational system based on a public data and naive bayes approach [J]. SAR QSAR Environ Res，2015，26(10)：783-793.
[23] Mervin LH，Afzal AM，Drakakis G，et al. Target prediction utilising negative bioactivity data covering large chemical space [J]. J Cheminform，2015，7：51.
[24] Steindl TM，Schuster D，Laggner C，et al. Parallel screening：a novel concept in pharmacophore modeling and virtual screening [J]. J Cheminform，2006，46(5)：2146-2157.
[25] Xu H，Aldrich MC，Chen Q，et al. Validating drug repurposing signals using electronic health records：a case study of metformin associated with reduced cancer mortality [J]. J Am Med Inform Assoc，2015，22(1)：179-191.
[26] 動脉网蛋壳研究院.2017医疗大数据和人工智能产业报告[R].2017：101-110.
[27] 金小桃.健康医疗大数据[M].北京：人民卫生出版社，2018：159-160.
(收稿日期：2019-05-07 本文编辑：李亚聪), 百拇医药(孙雅婧 李春漾 曾筱茜)