Wnt/LRP6信号通路对阿尔茨海默病突触功能影响的研究进展(4)
[18] Liu CC，Tsai CW，Deak F，et al. Deficiency in LRP6-mediated Wnt signaling contributes to synaptic Abnormalities and amyloid pathology in Alzheimer′s disease [J]. Neuron，2014，84(1)：63-77.
[19] Lee JH，Cheng R，Rogaeva E，et al. Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease [J]. Neurogenetics，2008，9(2)：127-138.
[20] Alarcón MA，Medina MA，Hu Q，et al. A novel functional low-density lipoprotein receptor-related protein 6 gene alternative splice variant is associated with Alzheimer′sdisease [J]. Neurobiol Aging，2013，34(6)：1709.eq-18.
[21] González H，Elgueta D，Montoya A，et al. Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases [J]. J Neuroimmunol，2014，274(1/2)：1-13.
[22] Giorgi FS，Saccaro LF，Galgani A，et al. The role of Locus Coeruleus in neuroinflammation occurring in Alzheimer′s disease [J]. Brain Res Bull，2019，153：47-58.
[23] Bronzuoli MR，Iacomino A，Steardo L，et al. Targeting neuroinflammation in Alzheimer′s disease [J]. Inflamm Res，2016，9：199-208.
[24] Ye ZJ，Go GW，Singh R，et al. LRP6 protein regulates low density lipoprotein(LDL)receptor-mediated LDLuptake. [J]. Biol Chem，2012，287(2)：1335-1344.
[25] Go GW，Srivastava R.，Hernandez-Ono A，et al. The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue [J]. Cell Metab，2014， 19(2)：209-220.
(收稿日期：2019-11-18 本文編辑：刘永巧), 百拇医药(王素 李一平 谢宁)
[19] Lee JH，Cheng R，Rogaeva E，et al. Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease [J]. Neurogenetics，2008，9(2)：127-138.
[20] Alarcón MA，Medina MA，Hu Q，et al. A novel functional low-density lipoprotein receptor-related protein 6 gene alternative splice variant is associated with Alzheimer′sdisease [J]. Neurobiol Aging，2013，34(6)：1709.eq-18.
[21] González H，Elgueta D，Montoya A，et al. Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases [J]. J Neuroimmunol，2014，274(1/2)：1-13.
[22] Giorgi FS，Saccaro LF，Galgani A，et al. The role of Locus Coeruleus in neuroinflammation occurring in Alzheimer′s disease [J]. Brain Res Bull，2019，153：47-58.
[23] Bronzuoli MR，Iacomino A，Steardo L，et al. Targeting neuroinflammation in Alzheimer′s disease [J]. Inflamm Res，2016，9：199-208.
[24] Ye ZJ，Go GW，Singh R，et al. LRP6 protein regulates low density lipoprotein(LDL)receptor-mediated LDLuptake. [J]. Biol Chem，2012，287(2)：1335-1344.
[25] Go GW，Srivastava R.，Hernandez-Ono A，et al. The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue [J]. Cell Metab，2014， 19(2)：209-220.
(收稿日期：2019-11-18 本文編辑：刘永巧), 百拇医药(王素 李一平 谢宁)