[摘要] 我国是消化道肿瘤的高发地区，早诊断、早治疗是降低胃癌死亡率的重要手段。建立胃黏膜上皮细胞恶性转化模型是研究胃早期癌变的方法之一。目前常用的模型诱导剂有亚硝基胍、幽门螺杆菌、鹅去氧胆酸、赭曲霉毒素A、非编码转录调控基因表达等，但尚缺乏成熟公认的标准。本文就近年来文献发表的胃黏膜上皮细胞恶性转化模型作一综述，介绍各类模型制备方法、胃黏膜上皮细胞的形态变化、分子表达差异及其致病原理，为后续实验研究提供参考。

    [关键词] 恶性转化;细胞模型;胃黏膜上皮细胞;癌前病变

    [中图分类号] R735.2 [文献标识码] A [文章编号] 1673-7210(2020)03(b)-0036-04

    [Abstract] China is a high incidence area of digestive tract tumors. Early diagnosis and early treatment are an important means to reduce the mortality of gastric cancer. The establishment of malignant transformation model of gastric mucosal epithelial cells is one of the important methods to study early gastric cancer. Currently model inducers include nitrosoguanidine ......