荆花胃康胶丸联合四联疗法治疗Hp阳性老年慢性胃炎的临床效果(1)
[摘要] 目的 探討荆花胃康胶丸联合四联疗法治疗幽门螺杆菌(Hp)阳性老年慢性胃炎的临床效果。 方法 选取2015年3月～2018年9月辽宁省丹东市中心医院收治的Hp阳性老年慢性胃炎患者112例，按照随机数字表法将其分为对照组和研究组，各56例。对照组予以四联疗法治疗，研究组在对照组的基础上加用荆花胃康胶丸治疗。比较两组临床疗效、中医症状积分、炎性因子水平、Hp根除率及不良反应情况。 结果 研究组临床总有效率高于对照组，差异有统计学意义(P < 0.05)。研究组Hp根除率明显高于对照组，差异有统计学意义(P < 0.05)。两组治疗90 d后胃脘胀满、嗳气反酸、胃痛、口苦口干症状积分均较治疗前降低，且研究组低于对照组(P < 0.05)。两组治疗90 d后血清hs-CRP、IL-6、TNF-α水平均较治疗前降低，且研究组低于对照组(P < 0.05)。两组治疗期间不良反应发生率比较，差异无统计学意义(P > 0.05)。 结论 荆花胃康胶丸联合四联疗法治疗Hp阳性老年慢性胃炎患者，可迅速改善临床症状，降低炎性因子水平，且用药安全性较好，疗效确切，具有一定的临床应用价值。
[关键词] 荆花胃康胶丸;四联疗法;幽门螺杆菌阳性;老年;慢性胃炎;临床疗效
[中图分类号] R256.3 [文献标识码] A [文章编号] 1673-7210(2020)06(c)-0155-04
[Abstract] Objective To explore clinical efficacy of Jinghua Weikang Capsules combined with quadruple therapy in the treatment of Helicobacter pylori (Hp) positive elderly chronic gastritis. Methods One hundred and twelve Hp positive elderly patients with chronic gastritis admitted to Dandong Central Hospital from March 2015 to September 2018 were selected and divided into control group and study group according to the random number table method， with 56 cases in each group. Control group was given quadruple therapy， and study group was treated with Jinghua Weikang Capsules on the basis of control group. Clinical efficacy， traditional Chinese medicine symptom score， inflammatory factors， Hp eradication rate and adverse reactions of two groups were compared. Results Total effective rate of study group was significantly higher than that of control group (P < 0.05). The eradication rate of Hp in study group was significantly higher than that in control group (P < 0.05). The scores of stomachache fullness， belching and acid regurgitation， stomachache， stomachache and xerostomia in two groups after 90 days of treatment were lower than those before treatment， and the scores in study group were lower than those in control group (P < 0.05). The levels of serum hs-CRP， IL-6 and TNF-α in two groups after 90 days treatment were lower than those before treatment， and the level in study group was lower than that in control group (P < 0.05). There was no significant difference in incidence of adverse reaction between two groups (P > 0.05). Conclusion Jinghua Weikang Capsules combined with quadruple therapy in the treatment of Hp positive elderly patients with chronic gastritis can rapidly improve clinical symptoms， reduce the level of inflammatory factors， and the medication is safe and effective， which has a certain clinical application value., 百拇医药(姜欣 刘丹 韩林 程力)
[关键词] 荆花胃康胶丸;四联疗法;幽门螺杆菌阳性;老年;慢性胃炎;临床疗效
[中图分类号] R256.3 [文献标识码] A [文章编号] 1673-7210(2020)06(c)-0155-04
[Abstract] Objective To explore clinical efficacy of Jinghua Weikang Capsules combined with quadruple therapy in the treatment of Helicobacter pylori (Hp) positive elderly chronic gastritis. Methods One hundred and twelve Hp positive elderly patients with chronic gastritis admitted to Dandong Central Hospital from March 2015 to September 2018 were selected and divided into control group and study group according to the random number table method， with 56 cases in each group. Control group was given quadruple therapy， and study group was treated with Jinghua Weikang Capsules on the basis of control group. Clinical efficacy， traditional Chinese medicine symptom score， inflammatory factors， Hp eradication rate and adverse reactions of two groups were compared. Results Total effective rate of study group was significantly higher than that of control group (P < 0.05). The eradication rate of Hp in study group was significantly higher than that in control group (P < 0.05). The scores of stomachache fullness， belching and acid regurgitation， stomachache， stomachache and xerostomia in two groups after 90 days of treatment were lower than those before treatment， and the scores in study group were lower than those in control group (P < 0.05). The levels of serum hs-CRP， IL-6 and TNF-α in two groups after 90 days treatment were lower than those before treatment， and the level in study group was lower than that in control group (P < 0.05). There was no significant difference in incidence of adverse reaction between two groups (P > 0.05). Conclusion Jinghua Weikang Capsules combined with quadruple therapy in the treatment of Hp positive elderly patients with chronic gastritis can rapidly improve clinical symptoms， reduce the level of inflammatory factors， and the medication is safe and effective， which has a certain clinical application value., 百拇医药(姜欣 刘丹 韩林 程力)