启膈化瘀汤在食管癌支架置入术后胃食管反流治疗中的应用效果(1)
[摘要] 目的 探討启膈化瘀汤在食管癌支架置入术后胃食管反流治疗中的应用效果。 方法 选取河北省中医院2017年6月—2018年8月收治的食管癌支架置入术后引发胃食管反流患者46例，按照随机数字表法将其分为两组。对照组23例给予雷贝拉唑钠肠溶胶囊口服，治疗组23例给予启膈化瘀汤治疗，两组均持续治疗4周。观察两组胃食管反流症状积分、临床疗效及胃镜疗效，采用健康调查简表(SF-36)评价患者的生活质量。 结果 两组治疗后胃食管反流症状积分均低于治疗前，且治疗组低于对照组，差异有统计学意义(P < 0.05)。两组治疗后临床疗效总有效率比较，差异无统计学意义(P > 0.05)。两组治疗后胃镜疗效总有效率比较，差异无统计学意义(P > 0.05)。两组治疗后躯体疼痛、精神健康评分均高于治疗前，且治疗组高于对照组，差异有统计学意义(P < 0.05)。结论 启膈化瘀汤对于食管癌支架置入术后引发胃食管反流，可有效缓解患者症状，改善食管黏膜损伤程度，同时提高患者的生活质量，其临床疗效优于单纯西药治疗。
[关键词] 启膈化瘀汤;食管癌;食管支架置入术后;胃食管反流
[中图分类号] R256.3 [文献标识码] A [文章编号] 1673-7210(2020)08(c)-0161-04
Application effect of Qige Huayu Decoction in the treatment of gastroesophageal reflux after esophageal cancer stent implantation
XU Yapei1 YANG Qian2 YANG Zhufeng1 DUAN Yangyang1 LI Bolin2 ZHAO Danyang2
1.Department of Gastroenterology， Hebei Hospital of Traditional Chinese Medicine， Hebei Province， Shijiazhuang 050011， China; 2.Department of Spleen and Stomach Diseases， Hebei Hospital of Traditional Chinese Medicine， Hebei Province， Shijiazhuang 050011， China
[Abstract] Objective To investigate application effect of Qige Huayu Decoction in the treatment of gastroesophageal reflux after esophageal cancer stent implantation. Methods Forty-six patients with gastroesophageal reflux after stent implantation in Hebei Hospital of Traditional Chinese Medicine from June 2017 to August 2018 were selected and divided into two groups according to random number table method. Control group (23 cases) was given Rabeprazole Sodium Enteric-coated Capsules orally， while treatment group (23 cases) was treated with Qige Huayu Decoction. Both groups were treated for four weeks. The symptom score of gastroesophageal reflux， clinical efficacy and gastroscopy efficacy of two groups were observed. Medical outcomes study short form-36 (SF-36) was used to evaluate the quality of life in patients. Results The scores of gastroesophageal reflux symptoms in two groups after treatment were lower than those before treatment， and treatment group was lower than that in control group， the differences were statistically significant (P < 0.05). There was no significant difference in total effective rate between two groups (P > 0.05). There was no significant difference in total effective rate of gastroscopy between two groups (P > 0.05). The physical pain and mental health scores of two groups after treatment were higher than those before treatment， and treatment group was higher than that in control group， the differences were statistically significant (P < 0.05). Conclusion Qige Huayu Decoction can effectively alleviate the symptoms， improve the degree of esophageal mucosal injury and improve the quality of life in patients with gastroesophageal reflux after stent implantation of esophageal cancer. Its clinical efficacy is better than that of Western medicine alone., 百拇医药(许亚培 杨倩 杨铸锋 段洋洋 李博林 赵丹阳)
[关键词] 启膈化瘀汤;食管癌;食管支架置入术后;胃食管反流
[中图分类号] R256.3 [文献标识码] A [文章编号] 1673-7210(2020)08(c)-0161-04
Application effect of Qige Huayu Decoction in the treatment of gastroesophageal reflux after esophageal cancer stent implantation
XU Yapei1 YANG Qian2 YANG Zhufeng1 DUAN Yangyang1 LI Bolin2 ZHAO Danyang2
1.Department of Gastroenterology， Hebei Hospital of Traditional Chinese Medicine， Hebei Province， Shijiazhuang 050011， China; 2.Department of Spleen and Stomach Diseases， Hebei Hospital of Traditional Chinese Medicine， Hebei Province， Shijiazhuang 050011， China
[Abstract] Objective To investigate application effect of Qige Huayu Decoction in the treatment of gastroesophageal reflux after esophageal cancer stent implantation. Methods Forty-six patients with gastroesophageal reflux after stent implantation in Hebei Hospital of Traditional Chinese Medicine from June 2017 to August 2018 were selected and divided into two groups according to random number table method. Control group (23 cases) was given Rabeprazole Sodium Enteric-coated Capsules orally， while treatment group (23 cases) was treated with Qige Huayu Decoction. Both groups were treated for four weeks. The symptom score of gastroesophageal reflux， clinical efficacy and gastroscopy efficacy of two groups were observed. Medical outcomes study short form-36 (SF-36) was used to evaluate the quality of life in patients. Results The scores of gastroesophageal reflux symptoms in two groups after treatment were lower than those before treatment， and treatment group was lower than that in control group， the differences were statistically significant (P < 0.05). There was no significant difference in total effective rate between two groups (P > 0.05). There was no significant difference in total effective rate of gastroscopy between two groups (P > 0.05). The physical pain and mental health scores of two groups after treatment were higher than those before treatment， and treatment group was higher than that in control group， the differences were statistically significant (P < 0.05). Conclusion Qige Huayu Decoction can effectively alleviate the symptoms， improve the degree of esophageal mucosal injury and improve the quality of life in patients with gastroesophageal reflux after stent implantation of esophageal cancer. Its clinical efficacy is better than that of Western medicine alone., 百拇医药(许亚培 杨倩 杨铸锋 段洋洋 李博林 赵丹阳)