[摘要]安全有效的活髓保存治疗方法一直是牙体牙髓病学研究的热点，但现有的治疗方法都存在许多不足。生物治疗近年来发展迅速，其中基因治疗和干细胞治疗能有效促进组织的修复与再生，在牙髓损伤修复中已有不少应用研究，本文就这方面的研究进展作一综述。

    [关键词]牙髓损伤；修复；基因治疗；干细胞治疗

    [中图分类号]R 781.05[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.01.013

    Biological therapy for dentin-pulp complex regeneration and repairLuo Chuanxia1,2, Lin Zhengmei1.(1. Dept. of Conservative Dentistry and Endodontics, Hospital of Stomatology, Guanghua School of Stomatology, Sun YatSen University, Guangzhou 510055, China; 2. Dept. of Stomatology, Guangzhou Panyu Central Hospital, Guangzhou 511400, China)

    [Abstract]Safe and effective approaches for dentin-pulp complex regeneration and repair are the focus of scien-tist’s research around the conservative dentistry. Whereas, all current therapies have limitations. Gene therapy and stem cell-based therapy which are brand-new biological therapies build more favorable situation for tissue regen-eration and repair comparing with traditional treatment. This review will summarize current knowledge of gene-and stem cell-based therapies for dentin-pulp complex regeneration and repair. ......