[摘要]口腔黏膜组织工程主要应用于修复因肿瘤切除、牙周病、外伤等导致的软组织缺损。以前的组织工程研究主要围绕上皮细胞培养方法的发展以及结缔组织支架材料的研发开展，本文将对口腔黏膜组织工程替代物的培养模式、支架结构、基质功能及临床应用进行综述，展示组织工程的新视角及口腔黏膜组织工程的新应用。

    [关键词]口腔黏膜；组织工程；新视角

    [中图分类号] Q 813.1[文献标志码] A[doi]10.3969/j.issn.1673-5749.2012.01.016

    New perspectives of oral mucosa engineeringChen Jie, Chen Lili, Liu Jiarong.(Dept. of Stomatology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China)

    [Abstract]Tissue-engineered oral mucosal equivalents have been developed for clinical applications, such as restore the soft tissue defects due to excision of tumor, parodontopathy, trauma and so on. In the last several decades, researches have mainly concentrated on the development of epithelial cell culture methods and introducing new dermal scaffolds. In this review we will focus on the oral mucosa equivalent reconstructed models, the scaffold, the important role of the extracellular matrix, and display the new concept of tissue engineering and the new application of oral mucosa tissue engineering.

    [Key words]oral mucosa；tissue engineering；new perspective ......