[摘要]核心结合因子α1(Cbfα1)是骨形成的关键基因，是决定间充质细胞向成骨细胞系分化的特异性转录因子。通过调节Cbfα1的表达可以调控骨细胞的发生和分化，维持正常的骨骼发育。机械力可激活一些信号通路进而促进Cbfα1的表达，进一步调控骨的发育和形成，胞外信号调控激酶(ERK)1/2信号通路是其中一条关键通路。

    [关键词]机械力；核心结合因子α1；胞外信号调控激酶；间充质干细胞

    [中图分类号]Q 291[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.01.024

    Advances in the research of extracellular signal-regulated kinase 1/2 signaling pathway on promoting the expression of core binding factorα1 by mechanical strainWu Yuqiong, Jiang Lingyong, Fang Bing.(Center of Craniofacial Orthodontic, Dept. of Oral and Maxillofacial Surgery, The Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China; Oral Bioengineering and Regenerative Medicine Laboratory, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China)

    [Abstract]Core binding factorα1(Cbfα1)is a key gene in bone formation, which determines the mesenchymal stem cells differentiating to osteoblast. It’s available to control the differentiation of the bone cells, and maintain the normal skeletal development by adjusting the Cbfα1 expression. Mechanical strain promotes the expression of Cbfα1 by activating several signaling pathway, then adjusts skeletal development and formation, of which extracellular signal-regulated kinase1/2(ERK1/2)signaling pathway is a key one. ......