[摘要]核因子-κB受体活化因子(RANK)及其配体(RANKL)在牙周炎患者的牙槽骨吸收中具有重要的作用，抑制RANKL/RANK通路，可有效抑制破骨细胞的分化和激活，从而抑制牙槽骨的吸收。骨保护蛋白(OPG)可和RANKL结合，干扰RANKL和RANK的结合，从而防止骨组织的过度破坏。本文就RANKL/RANK/OPG轴、RANKL/RANK/OPG与牙周炎、抑制RANKL/RANK通路治疗牙周炎的可行性等研究进展作一综述。

    [关键词]核因子-κB受体活化因子/核因子-κB受体活化因子配体通路；牙周治疗；牙槽骨吸收

    [中图分类号]Q 51[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.01.028

    Research advances on inhibition receptor activator of nuclear factor-κB and its ligand in periodontal treatmentChen Bin, Sun Weibin.(Dept. of Periodontics, The Affiliated Stomatological Hospital of Medical College, Nanjing University, Nanjing 210008, China)

    [Abstract]Receptor activator of nuclear factor-κB(RANK)/receptor activator of nuclear factor-κB ligand(RANKL)play a critical role in alveolar bone resorption though affecting osteoclasts formation and activation, therefore, we can inhibit periodontal bone resorption though RANKL/RANK inhibition. Osteoprotegerin(OPG)protects bone from excessive resorption by binding to RANKL and preventing it from binding to RANK. In this paper, we will review the relationship between RANKL/RANK/OPG signaling pathway and periodontal disease, and we will mainly focus on the possibility of periodontal treatment with RANKL/RANK inhibition. ......