[摘要]异基因造血干细胞移植是根治恶性血液病的最有效方法，而移植物抗宿主病(GVHD)是恶性血液病的主要并发症，也是患者移植术后死亡的主要原因。GVHD的口腔表现在所有移植术后并发症中占重要地位，而且对疾病的控制和患者的预后有着举足轻重的影响。本文就GVHD的发病机制、口腔临床表现及其治疗等研究进展作一综述。

    [关键词]移植物抗宿主病；口腔表现；治疗；恶性血液病

    [中图分类号]R 781.5[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.01.031

    Clinical manifestation and treatment of graft versus host disease in oral cavityWang Wei, Yao Hua.(Dept. of Stomatology, The Affiliated First Hospital of Medical College, Zhejiang University, Hangzhou 310003, China)[Abstract]Allogenic hematopoietic stem cell transplantation(HSCT)is the most effective treatment for malignant hematologic disease, while graft versus host disease(GVHD)is the main complication and leading cause of mortality in patients receiving HSCT. Oral cavity involvement occurs frequently in patients suffering from GVHD, and it may be the primary or even the only site of GVHD. It is essential for oral professionals to be familiar with various oral GVHD. This review discusses the pathogenesis, multifarious clinical manifestation, available evidence for diagnostic, and the progress of treatment in oral GVHD. The management of the oral GVHD seems to be important in the early diagnosis of GVHD. ......