[摘要]骨形态发生蛋白(BMP)是一种具有诱导新骨形成能力的生物活性分子，它与各种生物材料复合构成的各种释放系统用于临床的骨修复。目前，BMP复合胶原释放系统的建立和应用备受业界的关注，其中BMP与胶原的结合方式更是重中之重。本文就BMP复合胶原常用的胶原材料、BMP与胶原之间的结合方式等研究进展作一综述。

    [关键词]骨形态发生蛋白；胶原；释放系统

    [中图分类号]R 783.1[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.02.032

    Research progress on release system of bone morphogenetic protein and collagenZhang Quan, Deng Feilong.(Dept. of Implantation, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou 510055, China)

    [Abstract]Bone morphogenetic protein(BMP)is a kind of bioactive molecules with the ability to induce new bone formation, combined with a variety of biological materials to create various delivery systems for clinical bone repair. The establishment and application of the release system of BMP and collagen is the focus of current re-search, among which the binding mode of BMP and collagen is the most important. In this paper, the commonly used collagen materials of the release system of BMP and collagen as well as the binding mode of BMP and col-lagen are reviewed.

    [Key words]bone morphogenetic protein；collagen；release system ......