[摘要]苯妥英钠具有抗癫痫，治疗三叉神经和坐骨神经痛、发作性舞蹈手足徐动症、肌强直症，抗心律失常，降压等作用；但其所导致的牙龈增生不仅影响患者容貌的美观，还影响患者的口腔功能。本文就苯妥英钠性牙龈增生中的成纤维细胞增殖和程序性死亡，胶原的合成和降解，细胞外基质的积聚以及炎症反应等研究进展作一综述。

    [关键词]苯妥英钠；胶原；牙龈增生；炎症

    [中图分类号]Q 256[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.02.035

    Pathomechanism of phenytoin-induced gingival over-growthXiao Juan, Zhao Hui, Liu Fuxiang.(Dept. of Implantation, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)

    [Abstract]Phenytoin sodium is widely used to cure antiepileptic, trigeminal neuralgia, sciatica, paroxysmal choreoathetosis, myotonia, arrhythmia, hypertension and so, but a common and well-known adverse effect of its administration is gingival over-growth which may influence the aesthetics and oral function. The pathogenesis of Phenytoin sodium-induced gingival over-growth is not very clear now. This review summarized the mechanism of Phenytoin sodium-induced gingival over-growth, fibroblast cell proliferation and programmed cell death, collagen homeostasis, extracellular matrix accumulation and inflammation mechanism.

    [Key words]Phenytoin sodium；collagen；gingival over-growth；inflammation ......