[摘要]目的探讨白细胞介素(IL)-17和23在正常种植体和种植体周围炎中表达的异同，两者在种植体周围炎发生发展过程中的作用和相互关系。方法根据种植体周情况将其分为健康种植体组和炎症种植体组，以对侧同名健康天然牙为对照组。采集龈沟液并测量其体积，运用夹心酶联免疫吸附试验测定IL-17和23的质量浓度。结果在种植体周围炎患者龈沟液中，IL-17和23的质量浓度明显高于健康种植体组(P<0.01)，健康种植体组略高于对照组(P<0.05)。种植体周和天然牙周龈沟液的体积以及IL-17和23与牙周状况呈正相关关系，种植体周围龈沟液中IL-17与23呈线性正相关。结论IL-17和23的质量浓度与种植体周围炎的发生相关，种植体周IL-17与23间的质量浓度呈正相关，即IL-17和23可能在种植体周围炎症反应过程中形成了IL-23—IL-17免疫应答途径。

    [关键词]种植体；白细胞介素；种植体周龈沟液

    [中图分类号]Q 51[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.04.007

    The determination on the concentration of interleukin-17 and 23 in the peri-implant sulcular fluid of patientsChang Wei, Li Ying.(Dept. of Stomatology, The First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, China)

    [Abstract]ObjectiveTo explore the similarities and differences of the expression of interleukin(IL)-17 and 23 between the group of peri-implantitis and peri-implantar healthy patients. To determine the effect and mutual relations of IL-17 and 23 in the development and progression of peri-implantitis. MethodsImplant cases were divided into health-implant group and peri-implantitis group, the health of natural teeth of the opposite side with the same name as the control group. The peri-implant sulcular fluid were collected to determine the concentration of IL-17 and IL-23 by using enzyme-linked immunosorbent assay method. ResultsIn the peri-implant sulcular fluid of the peri-implantitis, the concentration of IL-17 and 23 was significantly higher than that in the implant group(P<0.01), health-implant group was slightly higher than that in the control group(P<0.05). The volume of implant and natural periodontal gingival crevicular fluid, and IL-17 and 23 had a positive correlation with periodontal status. There was a significant positive correlation between the concentration of IL-17 and IL-23 in the peri-implantitis group. ConclusionThe concentration of IL-17 and IL-23 were positively correlated with the incidence of peri-implantitis. IL-17 and IL-23 can form IL-23—IL-17 immune response pathway in the incidence of peri-implantitis. ......