[摘要]生物膜无处不在，绝大多数细菌是附着在有生命或无生命物体的表面，以生物膜方式生长，而非浮游方式生长。组成地球生命体的氨基酸几乎都是左旋的，但随着科学技术的进步和分析方法的发展，人们不断发现各种生物中含有多种天然的游离右旋氨基酸，因此，本文就右旋氨基酸对生物膜细菌细胞外基质的作用、细菌细胞壁的作用和细菌间自身诱导分子的作用等研究进展作一综述。

    [关键词]右旋氨基酸；生物膜；作用

    [中图分类号]R 780.2[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.06.033

    Research progress on the effect of D-amino acids on biofilmsZhou Han, Zhou Xuedong.(State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China)

    [Abstract]Most of the world’s bacteria exist in robust, sessile communities known as biofilms, ubiquitously predominate in most of the environmental, bacteria predominate, industrial, and medical processes. Even though Lamino acids are the dominant substrates for ribosome-basedprotein synthesis, several roles for D-amino acids in other biological processes have been found. This review summarized the previous researches on the effects that the D-amino acids have on the synthesis of extracellular polymeric substances in biofilms, the bacteria cell walls and signal molecule autoinducer-2 in recent years.

    [Key words]D-amino acid；biofilm；effect!!!!生物膜是指被其自身分泌的黏性胞外基质包裹 ......