青少年双生子体型指征相关指标的遗传度研究(英文)
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张栋 逄增昌 汪韶杰 宁峰 吴伟峰 兰金凤 张东峰 青岛大学医学院营养研究所;青岛市疾病预防控制中心;芬兰赫尔辛基大学公共卫生系;青岛大学医学院;
【摘要】目的:用经典的双生子设计探讨遗传因素对青少年身高、体重、体质指数(BMI)等体型指征的影响程度。方法:从青岛市双生子库中选择自愿参加本研究的362对11-19岁双生子,测量身高、体重。同性别的双生子通过16个多态标记进行卵型鉴定,在此基础上,应用Mx软件构建结构方程模型分析计算遗传度。结果:对362对有效双生子数据进行分析,其中同卵双生子194对,异卵双生子168对,身高的最佳拟合模型ACE模型,体重和BMI的最佳拟合模型为AE模型。调整年龄性别后,身高的遗传度为66%,体重的遗传度为84%,体质指数的遗传度为75%。结论:在青少年体型指征的相关指标中,身高、体重、BMI受遗传因素影响都较大。
【关键词】 青少年双生子 遗传度 结构方程模型 体型指征
【分类号】R394
IntroductionObesity among children and adolescents is considered aworldwide epidemic problem that is associated with medical andpsychological complications[1].The human physique is influencedby a variety of environmental factors,such as lifestyle,diet,an
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Introduction
Obesity among children and adolescents is considered a worldwide epidemic problem that is associated with medical and psychological complications The human physique is influenced by a variety of environmental factors, such as Iifestyle, diet, and physical activity Indeed, research has also shown the influence of genetic factors on anthropometric and body composition measures .The obesity epidemic is explained by factors such as sedentary lifestyles and high caloric diets . However, genetic factors have also been described as possible causes for obesity in children and adolescents . Twin studies have been widely used to determine heritability--the proportion of the total phenotypic variation attributable to genetic variance.
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