摘要 目的：优选心脑苏颗粒成型工艺。方法：运用单因素及正交试验设计，以颗粒吸湿率、成型率、休止角作为判定依据，优化辅料种类及用量、润湿剂的浓度，以确定最佳成型工艺条件。结果：优选辅料为糊精，浸膏与辅料用量为1∶1，90%乙醇作为润湿剂，干燥温度为60 ℃进行制备。结论：此法制备的心脑苏颗粒性质稳定、外观好、吸湿性小、溶化性好，可用于工业化生产。

    关键词 心脑苏颗粒；成型工艺；正交设计

    Abstract Objective：To optimize formation technology of Xinnaosu granules. Methods：A single factor and orthogonal experiment was designed. The particle moisture absorption rate， the forming rate and the repose angle were taken as judging conditions to optimize the type and dosage of auxiliary materials and the concentration of wetting agent. To determine the optimum molding processes conditions. Results：The dextrin was optimized as excipient. Prescription of the clear cream and excipient was set as 1：1 and 90% ethanol was set as wetting agent. The drying temperature was set as 60 degrees centigrade. Conclusion：Xinnaosu Granule prepared by this method has stable properties ......