手厥阴经电刺激联合醒脑静注射液对脑性昏迷患者疗效及对神经功能的影响(3)
脑缺血是脑性昏迷最主要的致病原因,而反复脑出血会对脑组织产生累积损伤效应,从而导致对脑组织缺血敏感区海马的显著损害,尤其是胆碱能神经元数量减少,Ach减少,脑内胆碱受体数目降低,继而会致使学习记忆功能障碍。而脑组织内各种单胺类神经递质是记忆形成的环节之一,主要包括5-HT、DA等。而临床上应用脑电地形图具有敏感性、直观性强以及可定量分析特点。本研究结果表明,2组DA和Ach治疗后升高,观察组DA和Ach治疗后高于对照组,说明手厥阴经电刺激联合醒脑静注射液可明显改善DA和Ach。
综上所述,手厥阴经电刺激联合醒脑静注射液对脑性昏迷患者疗效显著,可改善患者神经功能,具有重要临床研究意义。
参考文献
[1]Varano P,Cabrera K I,Kuppermann N,et al.Acute outcomes of isolated cerebral contusions in children with Glasgow Coma Scale scores of 14 to 15 after blunt head trauma[J].Journal of Trauma & Acute Care Surgery,2015,78(5):1039-1043.
, 百拇医药
[2]黄春敏,孙剑虹.基于脑性昏迷患者感知水平的唤醒干预对其觉醒意识及预后的影响[J].中华护理杂志,2016,51(1):29-34.
[3]Shabani E.High Plasma Erythropoietin Levels are Associated With Prolonged Coma Duration and Increased Mortality in Children WithCerebral Malaria[J].Clinical Infectious Diseases An Official Publication of the Infectious Diseases Society of America,2015,60(1):27-35.
[4]林允照,林朦朦,欧阳吟靖,等.感知行为干预对重度脑性昏迷患者意识状态及神经功能的影响[J].中华灾害救援医学,2014,2(12):670-674.
, 百拇医药
[5]Varano P,Cabrera K I,Kuppermann N,et al.Acute outcomes of isolated cerebral contusions in children with Glasgow Coma Scale scores of 14 to 15 after blunt head trauma[J].Journal of Trauma & Acute Care Surgery,2015,78(5):1039-1043.
[6]贾建平,崔丽英,王伟,等.神经病学[M].6版.北京:人民卫生出版社,2009:317.
[7]郑莜萸.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:89-93.
[8]梁文海.右正中神经电刺激治疗颅脑创伤性昏迷的研究[J].中国临床新医学,2016,9(3):197-201.
, http://www.100md.com
[9]Kumar R,Singhi S,Singhi P,et al.Randomized controlled trial comparing cerebral perfusion pressure-targeted therapy versus intracranial pressure-targeted therapy for raised intracranial pressure due to acute CNS infections in children[J].Critical Care Medicine,2014,42(8):1775-1787.
[10]梁文海.右正中神經电刺激治疗颅脑创伤性昏迷的研究[J].中国临床新医学,2016,9(3):197-201.
[11]高国一.急性颅脑损伤导致昏迷的救治[J].中华神经创伤外科电子杂志,2015,1(6):55-56.
, 百拇医药 [12]韦鹏翔,孙龙,刘四新,等.手厥阴经电刺激对脑性昏迷患者促醒作用的初步研究[J].神经疾病与精神卫生,2007,7(3):169-171.
[13]孙龙,韦鹏翔.手厥阴经电刺激对脑性昏迷的治疗[J].神经疾病与精神卫生,2007,7(4):308-310.
[14]朱强.醒脑静注射液治疗颅脑外伤昏迷24例[J].河南中医,2015,35(9):2099-2100.
[15]周喜平.醒脑静注射液治疗脑卒中后昏迷疗效观察[J].中西医结合心脑血管病杂志,2012,10(6):694-695.
[16]林峰.醒脑静注射液对急性脑卒中昏迷伴中枢性高热的疗效[J].中医学报,2014,24(12):362-363.
(2016-11-15收稿 责任编辑:王明), 百拇医药(刘四新 崔国胜 刘刚)
综上所述,手厥阴经电刺激联合醒脑静注射液对脑性昏迷患者疗效显著,可改善患者神经功能,具有重要临床研究意义。
参考文献
[1]Varano P,Cabrera K I,Kuppermann N,et al.Acute outcomes of isolated cerebral contusions in children with Glasgow Coma Scale scores of 14 to 15 after blunt head trauma[J].Journal of Trauma & Acute Care Surgery,2015,78(5):1039-1043.
, 百拇医药
[2]黄春敏,孙剑虹.基于脑性昏迷患者感知水平的唤醒干预对其觉醒意识及预后的影响[J].中华护理杂志,2016,51(1):29-34.
[3]Shabani E.High Plasma Erythropoietin Levels are Associated With Prolonged Coma Duration and Increased Mortality in Children WithCerebral Malaria[J].Clinical Infectious Diseases An Official Publication of the Infectious Diseases Society of America,2015,60(1):27-35.
[4]林允照,林朦朦,欧阳吟靖,等.感知行为干预对重度脑性昏迷患者意识状态及神经功能的影响[J].中华灾害救援医学,2014,2(12):670-674.
, 百拇医药
[5]Varano P,Cabrera K I,Kuppermann N,et al.Acute outcomes of isolated cerebral contusions in children with Glasgow Coma Scale scores of 14 to 15 after blunt head trauma[J].Journal of Trauma & Acute Care Surgery,2015,78(5):1039-1043.
[6]贾建平,崔丽英,王伟,等.神经病学[M].6版.北京:人民卫生出版社,2009:317.
[7]郑莜萸.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:89-93.
[8]梁文海.右正中神经电刺激治疗颅脑创伤性昏迷的研究[J].中国临床新医学,2016,9(3):197-201.
, http://www.100md.com
[9]Kumar R,Singhi S,Singhi P,et al.Randomized controlled trial comparing cerebral perfusion pressure-targeted therapy versus intracranial pressure-targeted therapy for raised intracranial pressure due to acute CNS infections in children[J].Critical Care Medicine,2014,42(8):1775-1787.
[10]梁文海.右正中神經电刺激治疗颅脑创伤性昏迷的研究[J].中国临床新医学,2016,9(3):197-201.
[11]高国一.急性颅脑损伤导致昏迷的救治[J].中华神经创伤外科电子杂志,2015,1(6):55-56.
, 百拇医药 [12]韦鹏翔,孙龙,刘四新,等.手厥阴经电刺激对脑性昏迷患者促醒作用的初步研究[J].神经疾病与精神卫生,2007,7(3):169-171.
[13]孙龙,韦鹏翔.手厥阴经电刺激对脑性昏迷的治疗[J].神经疾病与精神卫生,2007,7(4):308-310.
[14]朱强.醒脑静注射液治疗颅脑外伤昏迷24例[J].河南中医,2015,35(9):2099-2100.
[15]周喜平.醒脑静注射液治疗脑卒中后昏迷疗效观察[J].中西医结合心脑血管病杂志,2012,10(6):694-695.
[16]林峰.醒脑静注射液对急性脑卒中昏迷伴中枢性高热的疗效[J].中医学报,2014,24(12):362-363.
(2016-11-15收稿 责任编辑:王明), 百拇医药(刘四新 崔国胜 刘刚)