阿尔茨海默病发病机制及药物治疗研究进展(4)
[10]Zheng H，Youdim MB，Fridkin M.Selective acetylcholinesterase inhibitor activated by acetylcholinesterase releases an active chelator with neurorescuing and anti-amyloid activities[J].ACS Chemical Neuroscience，2010，1(11)：737-746.
[11]Mc Geer PL，Rogers J，Mc Geer EC.Neuroimmunemechanisms in Alzheimer disease pathog-enesis[J].Alzheimer Dis Assoc Discord，1994，8(3)：149-158.
[12]马英，曹云鹏.阿尔茨海默病的神经免疫炎症发病机制及其治疗研究进展[J].中国老年学杂志，2010，30(21)：3200-3204.
, http://www.100md.com
[13]Joshi P，Turola E，Ruiz A，et al.Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles[J].Cell Death and Differentiation，2014，21：582-593.
[14]Alex E.Roher，David H.Cribbs，Ronald C.Kim，et al.Bapineuzumab Alters Aβ Composition：Implications for the Amyloid Cascade Hypothesis and Anti-Amyloid Immunotherapy[J].PLOS One，2013，8(3)：e59735.
[15]Brawek B1，Garaschuk O.Network-wide dysregulation of calcium homeostasis in Alzheimer′s disease[J].Cell and Tissue Research，2014，357(2)：427-438.
, 百拇医药
[16]陈茜茜，苏涛.微循环在阿尔茨海默病发生发展中的作用[J].生物化学与生物物理进展，2015，41(12)：1077-1083.
[17]Bolognin S，Messori L，Drago D，et al.Copper，iron and zinc differentially alter amyloid-Aβ(1-42) aggregation and toxicity[J].The International Journal of Biochemistry & Cell Biology，2011，43(6)：877-885.
[18]Butterfield DA，Di Domenico F，Barone E.Elevated risk of type 2 diabetes for development of Alzheimer disease：a key role for oxidative stress in brain[J].Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease，2014，1842(9)：1693-1706.
, 百拇医药
[19]許保磊，王蓉.兴奋性氨基酸转运体2在神经退行性变中的作用[J].中国比较医学杂志，2012，22(10)：67-71.
[20]Do TD，Economou NJ，Chamas A，et al.Interactions between Amyloid-β and Tau Fragments Promote Aberrant Aggregates：Implications for Amyloid Toxicity[J].J Phys Chem B，2014，118(38)：11220-11230.
[21]CATALDO A M，PETERHOFF C M，TRONCOSO J C，et al.Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer′s disease and Downsyndrome：Differential effects of APOE genotype and presenilin mutations[J].Am J Pathol，2000，157(3)：277-286.
, 百拇医药
[22]SanjayW，Pimplikar.Reassessing the amyloid cascade hypothesis of Alzheim er′s disease[J].The International JournalofBiochemis-try& CellBiology，2009，41：1261-1268.
[23]董雯，郑爽.阿尔茨海默病病因及发病机制的研究[J].中国老年保健医学，2011，9(1)：37-39.
[24]Edgünlü TG，Ozge A，Yaln O，et al.A Study of the Impact of Death Receptor 4 (DR4) Gene Polymorphisms in Alzheimer′s Disease[J].Balkan Med J，2013，30(3)：268-272., 百拇医药(张琳琳 宋宛珊 王凯)
[11]Mc Geer PL，Rogers J，Mc Geer EC.Neuroimmunemechanisms in Alzheimer disease pathog-enesis[J].Alzheimer Dis Assoc Discord，1994，8(3)：149-158.
[12]马英，曹云鹏.阿尔茨海默病的神经免疫炎症发病机制及其治疗研究进展[J].中国老年学杂志，2010，30(21)：3200-3204.
, http://www.100md.com
[13]Joshi P，Turola E，Ruiz A，et al.Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles[J].Cell Death and Differentiation，2014，21：582-593.
[14]Alex E.Roher，David H.Cribbs，Ronald C.Kim，et al.Bapineuzumab Alters Aβ Composition：Implications for the Amyloid Cascade Hypothesis and Anti-Amyloid Immunotherapy[J].PLOS One，2013，8(3)：e59735.
[15]Brawek B1，Garaschuk O.Network-wide dysregulation of calcium homeostasis in Alzheimer′s disease[J].Cell and Tissue Research，2014，357(2)：427-438.
, 百拇医药
[16]陈茜茜，苏涛.微循环在阿尔茨海默病发生发展中的作用[J].生物化学与生物物理进展，2015，41(12)：1077-1083.
[17]Bolognin S，Messori L，Drago D，et al.Copper，iron and zinc differentially alter amyloid-Aβ(1-42) aggregation and toxicity[J].The International Journal of Biochemistry & Cell Biology，2011，43(6)：877-885.
[18]Butterfield DA，Di Domenico F，Barone E.Elevated risk of type 2 diabetes for development of Alzheimer disease：a key role for oxidative stress in brain[J].Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease，2014，1842(9)：1693-1706.
, 百拇医药
[19]許保磊，王蓉.兴奋性氨基酸转运体2在神经退行性变中的作用[J].中国比较医学杂志，2012，22(10)：67-71.
[20]Do TD，Economou NJ，Chamas A，et al.Interactions between Amyloid-β and Tau Fragments Promote Aberrant Aggregates：Implications for Amyloid Toxicity[J].J Phys Chem B，2014，118(38)：11220-11230.
[21]CATALDO A M，PETERHOFF C M，TRONCOSO J C，et al.Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer′s disease and Downsyndrome：Differential effects of APOE genotype and presenilin mutations[J].Am J Pathol，2000，157(3)：277-286.
, 百拇医药
[22]SanjayW，Pimplikar.Reassessing the amyloid cascade hypothesis of Alzheim er′s disease[J].The International JournalofBiochemis-try& CellBiology，2009，41：1261-1268.
[23]董雯，郑爽.阿尔茨海默病病因及发病机制的研究[J].中国老年保健医学，2011，9(1)：37-39.
[24]Edgünlü TG，Ozge A，Yaln O，et al.A Study of the Impact of Death Receptor 4 (DR4) Gene Polymorphisms in Alzheimer′s Disease[J].Balkan Med J，2013，30(3)：268-272., 百拇医药(张琳琳 宋宛珊 王凯)