丹参多酚酸对全髓关节置换术后血流动力学参数的影响(1)

http://www.100md.com 2017年4月1日 《世界中医药》 20177

     摘要 目的：观察丹参多酚酸对全髓关节置换术前后无创血流动力学参数的影响。方法：选取2016年3月1日至2017年2月1日福州总医院九五临床部骨科住院部就诊的符合全髋关节置换术患者60例，根据随机数字表法分为观察组和对照组，每组30例，对照组常规全髋关节置换术操作，观察组基于对照组基础上施予丹参多酚酸注射液。在颈内静脉穿刺放置动脉漂浮导管，连接多功能监护仪和无创血流动力学监测仪对患者血气参数、血压和血流动力学进行记录和监测，同时监测患者治疗前后血液流变学参数。结果：1)2组术中血气血压参数具有可比性( P >0.05)。2)术后2组全血高切黏度、全血低切黏度、血细胞比容、血浆黏度均降低( P <0.05)，且观察组各指标均低于对照组( P <0.05)。3)2组术后无创血流动力学最大峰值流速、舒张末流速、血管搏动指数、血管阻力指数均升高( P <0.05)，且观察组各指标均优于对照组( P <0.05)。结论：丹参多酚酸可以降低全髋关节置换术患者的血液黏滞度，改善其血流动力学参数，提高患者术后恢复情况。

    关键词 丹参多酚酸；全髓关节置换术；无创血流动力学参数
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    Effect of Salvianolate on Noninvasive Hemodynamic Parameters after Total Hip Arthroplasty

    Xie Xiayoyong， Li Zhi， Gong Jun

    (The First Affiliated Hospital of Fuzhou General Hospital of Nanjing Military Command， Putian 351100， China)

    Abstract Objective： To observe the effect of salvianolate on the noninvasive hemodynamic parameters after total hip arthroplasty. Methods： Sixty inpatient patients who had total hip arthroplasty in March 1， 2016 to February 1st 2017 in the department of orthopedics of the hospital were selected and were randomly divided into observation group and control group， with 30 cases in each group. Patients in the control group received conventional total hip replacement operation， while patients in the observation group additionally received salvianolate injection. Arterial floating catheter was placed by internal jugular vein puncture， and multi-functional monitor and noninvasive hemodynamic monitor were connected to record and monitor blood gas parameters， blood pressure and hemodynamics of patients before and after the treatment. Blood rheology parameters were monitored at the same time. Results： 1) The parameters of blood gas and blood pressure were comparable in the two groups ( P >0.05). 2) After the operation of two groups， high blood viscosity， low blood viscosity， hematocrit and plasma viscosity all decreased ( P <0.05)， but those of the observation group was significantly lower ( P <0.05). 3) The maximal peak velocity， the end diastolic velocity， pulsatility index and vascular resistance index of the two groups increased ( P <0.05) and those of the observation group were higher than those of the control group ( P <0.05). Conclusion： Salvianolate can reduce the blood viscosity of patients who had total hip arthroplasty， improve the hemodynamic parameters and enhance the recovery of patients.

    Key Words Salvianolate； Total hip replacement； Noninvasive hemodynamic parameters

    中圖分类号：R274.9 文献标识码：A doi： 10.3969/j.issn.1673-7202.2017.07.030, http://www.100md.com(谢晓勇 李智 龚骏)

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