荷芪散联合二甲双胍治疗多囊卵巢综合征伴胰岛素抵抗的临床研究(1)

http://www.100md.com 2017年4月15日 《世界中医药》 20178

     摘要 目的：研究荷芪散聯合二甲双胍对多囊卵巢综合征(Polycystic Ovary Syndrome，PCOS)伴胰岛素抵抗(Insulin Resistance，IR)的临床疗效。方法：选取2015年1月至2016年1月深圳市中医院住院及门诊治疗的多囊卵巢综合征患者共90例，随机分为A组(中药组)、B组(西药组)、C组(中西药组)，每组30例。中药组予荷芪散，西药组予二甲双胍，中西药组予荷芪散加二甲双胍。观察治疗前后临床症状、糖代谢及胰岛素抵抗指标、性激素水平的变化。结果：治疗3个月后，中西药组临床症状改善优于中药组及西药组(P<0.05)；西药组、中西药组均可显著降低胰岛素(FINS、2 hINS)水平、稳态胰岛素评价指数(HOMA-IR)(P<0.01)，提高胰岛素敏感性指数(ISI)(P<0.01)，中西药组比西药组治疗效果更显著，差异有统计学意义(P<0.05)。中药组与中西药组能降低血清黄体生成素(Luteinizing Hormone，LH)(P<0.01)、睾酮(Testosterone，T)水平(P<0.05，P<0.01)，而西药组仅可降低T水平(P<0.01)。结论：荷芪散联合二甲双胍可改善多囊卵巢综合征伴胰岛素抵抗患者的临床症状和胰岛素抵抗，调节胰岛素及性激素水平。
, http://www.100md.com
    关键词 多囊卵巢综合征；荷芪散；二甲双胍；胰岛素抵抗；性激素

    Clinical Study on Heqi Powder Combined with Metformin in Treating Polycystic Ovary Syndrome with Insulin Resisitance

    Liu Ling1， Zhao Hengxia1， Li Huilin1， Chu Shufang1， Liu Xuemei1， Liu Deliang1，Zhang Xuewen2

    (1 Endocrine Department， Shenzhen Hospital of Traditional Medicine， Shenzhen 518033， China； 2 Shaanxi University of traditional Chinese medicine， Xianyang 712046， China)
, 百拇医药
    Abstract Objective：To observe the clinical curative effect of Heqi Powder combined with Metformin in treating PCOS with insulin resistance.Methods：Ninety patients who met the criteria were included and randomly divided into group A (Chinese medicine group)， group B (western medicine group) and group C (Chinese-western medicine group)， with 30 cases in each group. Chinese medicine group took Heqi Powder， western medicine group took metformin， while the Chinese-western medicine group took Heqi Powder plus metformin. Clinical syndromes， glucose metabolic and insulin resistant parameters and sex hormone levels of the two groups before and after the treatment were compared.Results：After 3-month treatment， improvement in clinical syndromes of the Chinese-western medicine group was better than Chinese group and western medicine group (P<0.05). Insulin level and HOMA-IR in the western group and Chinese-western medicine group decreased effectively (P<0.01)， ISI increased (P<0.01). The Chinese-western medicine group received better results， showing that the difference between the two groups was significant (P<0.05). LH (P<0.01) and T level (P<0.05，P<0.01) in the Chinese group and the Chinese-western medicine group decreased， but T level only decreased in the western medicine group (P<0.01).Conclusion：Heqi Powder combined with Metformin may improve patients′ clinical syndromes and insulin resistance and regulate insulin and sex hormone levels for patients with PCOS with insulin resistance., 百拇医药(刘玲 赵恒侠 李惠林 楚淑芳 刘雪梅 刘德亮 张学文)

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