“凤香洗液”对高危HPV感染者和CINⅠ患者宫颈局部体液免疫的影响(1)
摘要 目的：观察高危人乳头瘤病毒(Human Papillomavirus，HPV)感染及伴宫颈上皮内瘤变(Cervical Intraepithelial Neoplasia，CIN I)的患者宫颈局部体液免疫因子的变化及中药“凤香洗液”对其干预作用。方法：选取单纯高危HPV感染者50例(HPV组)、高危HPV感染伴CINⅠ者50例(CINⅠ组)，同期健康妇女50例作对照组。HPV组及CINⅠ组给予中药“凤香洗液”治疗，留取各组患者治疗前后阴道灌洗液，ELISA法测定SIgA、IgG、IgE浓度。结果：用药前HPV组和CINⅠ组SIgA浓度显著低于对照组(P<0.01)，CINⅠ组变化更显著(P<0.01)，HPV组IgG、IgE浓度显著高于对照组(P<0.01)，而CINⅠ组IgG、IgE浓度显著低于对照组(P<0.01)；HPV组用药后SIgA浓度显著升高(P<0.01)，IgG、IgE浓度显著下降(P<0.01)；CINⅠ组用藥后SIgA、IgG、IgE浓度均显著升高(P<0.01)；HPV组、CINⅠ组用药后SIgA、IgG、IgE水平与正常组比较，差异均无统计学意义(P>0.05)。结论：单纯高危HPV感染及伴CINⅠ的患者宫颈局部体液免疫因子发生异常改变，中药“凤香洗液”能有效改善宫颈局部体液免疫状态。
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关键词 HPV；CIN；“凤香洗液”；体液免疫
Abstract Objective：To observe the changes in the local humoral immune factors in the cervix and interventional effects of the “Fengxiang Lotion” on these factors in patients with high-risk HPV infection and CIN I. Methods：Fifty patients with simple high-risk HPV infection (HPV group)， 50 patients with high-risk HPV infection associated with CIN I (CIN I group) and 50 healthy women (control group) were selected. In the HPV group and CIN I group， patients were given the TCM “Fengxiang Lotion” as treatment； the vaginal lavage was retained before and after treatment； and the SIgA， IgG and IgE expression levels were detected using ELISA method. Results：Before treatment， the SIgA concentration was significantly lower in the HPV group and CIN I group than that in the control group (P<0.01)； the changes were more remarkable in the CIN I group than that in the HPV group (P<0.01)； the IgG and IgE concentrations were significantly higher in the HPV group than that in the control group (P<0.01)， while the IgG and IgE concentrations were significantly lower in CIN I group than that in the control group (P<0.01)； After treatment， there was a significant increase in SIgA concentration (P<0.01) and a significant decrease in IgG and IgE concentrations in the HPV group (P<0.01)； After treatment， there were a significant increase in SIgA， IgG and IgE concentrations in the CIN I group (P<0.01)； There were no statistically significant difference in post-treatment SIgA， IgG or IgE level between the control group and the HPV or CIN I group (P>0.05). Conclusion：In patients with high-risk HPV infection and CIN I， there are abnormal changes in the local humoral immune factors in cervix， such as SIgA， IgG and IgE， and “Fengxiang Lotion” effectively improves the local humoral immune state in cervix.
Key Words Human papillomavirus (HPV)； Cervical intraepithelial neoplasia (CIN)； Fengxiang Lotion； Humoral immunity, 百拇医药(李小宁 刘霞 桂晓凤)
, http://www.100md.com
关键词 HPV；CIN；“凤香洗液”；体液免疫
Abstract Objective：To observe the changes in the local humoral immune factors in the cervix and interventional effects of the “Fengxiang Lotion” on these factors in patients with high-risk HPV infection and CIN I. Methods：Fifty patients with simple high-risk HPV infection (HPV group)， 50 patients with high-risk HPV infection associated with CIN I (CIN I group) and 50 healthy women (control group) were selected. In the HPV group and CIN I group， patients were given the TCM “Fengxiang Lotion” as treatment； the vaginal lavage was retained before and after treatment； and the SIgA， IgG and IgE expression levels were detected using ELISA method. Results：Before treatment， the SIgA concentration was significantly lower in the HPV group and CIN I group than that in the control group (P<0.01)； the changes were more remarkable in the CIN I group than that in the HPV group (P<0.01)； the IgG and IgE concentrations were significantly higher in the HPV group than that in the control group (P<0.01)， while the IgG and IgE concentrations were significantly lower in CIN I group than that in the control group (P<0.01)； After treatment， there was a significant increase in SIgA concentration (P<0.01) and a significant decrease in IgG and IgE concentrations in the HPV group (P<0.01)； After treatment， there were a significant increase in SIgA， IgG and IgE concentrations in the CIN I group (P<0.01)； There were no statistically significant difference in post-treatment SIgA， IgG or IgE level between the control group and the HPV or CIN I group (P>0.05). Conclusion：In patients with high-risk HPV infection and CIN I， there are abnormal changes in the local humoral immune factors in cervix， such as SIgA， IgG and IgE， and “Fengxiang Lotion” effectively improves the local humoral immune state in cervix.
Key Words Human papillomavirus (HPV)； Cervical intraepithelial neoplasia (CIN)； Fengxiang Lotion； Humoral immunity, 百拇医药(李小宁 刘霞 桂晓凤)