丹红注射液治疗短暂性脑缺血发作的疗效分析及对患者血流动力学及神经功能的影响(1)
摘要 目的：探討丹红注射液对短暂性脑缺血发作(TIA)患者的疗效及对其血流动力学、神经功能及其他血生化指标的影响。方法：选取2015年6月至2016年2月陆军总医院附属八一脑科医院收治的TIA患者86例，随机分为观察组和对照组，每组43例。对照组采用常规西医治疗，观察组在对照组的基础上加用丹红注射液治疗，2组均连续治疗14 d，于治疗结束后均至少随访3个月。评价2组患者的临床疗效，检测并比较2组患者血流动力学指标、神经功能指标及其他血生化指标水平的变化。结果：治疗后2组Vmean、Vmax、Vmin、Qmean均较治疗前显著增大，R较治疗前显著下降(P<0.05或P<0.01)，且2组间差异有统计学意义(P<0.05或P<0.01)；治疗后2组血清S-100B、GFAP、NSE、MBP等神经功能指标水平，血清Cys-c、Hcy、CD62p、CD63水平均较治疗前显著下降(P<0.05或P<0.01)，且观察组显著低于对照组(P<0.05或P<0.01)；观察组复发率为11.63%、脑梗死发生率为6.98%，均显著低于对照组的34.88%、25.58%(P<0.05)。结论：丹红注射液治疗TIA，复发率低，脑梗死发生率低，血流动力学得到明显改善，脑血流速度加快，并能有效抑制血小板活化功能，进而促进患者神经功能恢复。
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关键词 短暂性脑缺血发作；丹红注射液；血流动力学；神经功能；血生化
Abstract Objective：To investigate the therapeutic effects of Danhong Injection in treating transient ischemic attack (TIA) and the influence on patient′s hemodynamics，neurological function and other blood biochemical indexes.Methods：A total of 86 patients with TIA who were admitted and treated in our hospital were randomly divided into treatment group and control group with 43 patients in each group.The control group received conventional western medicine treatment，and the treatment group was added Danhong Injection.Both groups were treated continuously for 14 d，with at least 3 months′ follow-up visit after treatment.The therapeutic effects of 2 groups were evaluated，and the changes of hemodynamics，neurological function and other blood biochemical indexes were detected and compared.Results：The Vmean，Vmax，Vmin，Qmean of two groups were increased compared with that before treatment，and R was significantly decreased (P<0.05 or P<0.01).The difference between 2 groups was significant (P<0.05 or P<0.01).The neurological function indexes levels of serum S-100B，GFAP，NSE，MBP，and Cys-c，Hcy，CD62p，CD63 were significantly decreased compared with that before treatment (P<0.05 or P<0.01)，and the treatment group was significantly lower than the control group (P<0.05 or P<0.01).The recurrence rate and incidence rate of cerebral infarction in treatment group were 11.63% and 6.98%，which was lower than 34.88% and 25.58% in control group (P<0.05).Conclusion：Danhong Injection in treating TIA has low recurrence rate and low incidence rate of cerebral infraction，and can significantly improve hemodynamics and accelerate cerebral blood flows，as well as effectively inhibit hematoblastic activation function to further improve the recovery of patient′s neurological function.
Key Words Transient ischemic attack；Danhong injection；Hemodynamics；Nerve function； Blood biochemistry, 百拇医药(曹樱花)
, http://www.100md.com
关键词 短暂性脑缺血发作；丹红注射液；血流动力学；神经功能；血生化
Abstract Objective：To investigate the therapeutic effects of Danhong Injection in treating transient ischemic attack (TIA) and the influence on patient′s hemodynamics，neurological function and other blood biochemical indexes.Methods：A total of 86 patients with TIA who were admitted and treated in our hospital were randomly divided into treatment group and control group with 43 patients in each group.The control group received conventional western medicine treatment，and the treatment group was added Danhong Injection.Both groups were treated continuously for 14 d，with at least 3 months′ follow-up visit after treatment.The therapeutic effects of 2 groups were evaluated，and the changes of hemodynamics，neurological function and other blood biochemical indexes were detected and compared.Results：The Vmean，Vmax，Vmin，Qmean of two groups were increased compared with that before treatment，and R was significantly decreased (P<0.05 or P<0.01).The difference between 2 groups was significant (P<0.05 or P<0.01).The neurological function indexes levels of serum S-100B，GFAP，NSE，MBP，and Cys-c，Hcy，CD62p，CD63 were significantly decreased compared with that before treatment (P<0.05 or P<0.01)，and the treatment group was significantly lower than the control group (P<0.05 or P<0.01).The recurrence rate and incidence rate of cerebral infarction in treatment group were 11.63% and 6.98%，which was lower than 34.88% and 25.58% in control group (P<0.05).Conclusion：Danhong Injection in treating TIA has low recurrence rate and low incidence rate of cerebral infraction，and can significantly improve hemodynamics and accelerate cerebral blood flows，as well as effectively inhibit hematoblastic activation function to further improve the recovery of patient′s neurological function.
Key Words Transient ischemic attack；Danhong injection；Hemodynamics；Nerve function； Blood biochemistry, 百拇医药(曹樱花)
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