麻杏二陈三子汤对小儿哮喘急性发作的疗效及其对免疫机制的影响(1)
摘要 目的：探讨麻杏二陈三子汤对小儿哮喘急性发作的疗效及其对免疫机制的影响。方法：选取2014年8月至2016年12月宝鸡市中医医院收治的因哮喘急性发作入院治疗的患儿90例，按照随机数表法将入组患儿分为对照组、观察组各45例。对照组患儿接受临床常规治疗，观察组患儿接受常规+麻杏二陈三子汤治疗。比较2组患儿的疗效及Th17/Treg细胞免疫、Th1/Th2细胞免疫水平的差异。结果：治疗后，观察组患儿的治疗总有效率高于对照组患儿(P<0.05)；观察组患儿外周血中Th17细胞比例、Th17/Treg比值低于对照组患儿，Treg细胞比例高于对照组患儿(P<0.05)；观察组患儿血清中Th1细胞因子IL-2、IFN-γ的含量高于对照组患儿，Th2细胞因子IL-4、IL-10的含量低于对照组患儿(P<0.05)。结论：麻杏二陈三子汤治疗小儿哮喘急性发作，可有效提升整体疗效、优化机体免疫功能。
关键词 哮喘急性发作；麻杏二陈三子汤；Th17/Treg；Th1/Th2
Abstract Objective：To study the curative effects of Maxing Erchen Sanzi Decoction on children with acute episode of bronchial asthma and its influence on immune mechanism.Methods：A total of 90 children with acute episode of bronchial asthma who were treated in our hospital from August 2014 to December 2016 were selected and randomly divided into control group and observation group with 45 cases in each group according to random number table.Patients in control group were treated with routine treatment，and those in observation group were added Maxing Erchen Sanzi Decoction.The curative effects，the differences of Th17/Treg cell immunity and Th1/Th2 cell immunity between two groups were compared.Results：After treatment，the total efficiency in observation group was higher than that in control group (P<0.05)； The peripheral blood Th17 cell proportion and Th17/Treg ratio in observation group were lower than that in control group，and the proportion of Treg cells was higher than that in control group (P<0.05)； serum contents of Th1 cell factors such as IL-2 IFN-γwere higher than those in control group，and contents of Th2 cytokines such as IL-4，IL-10 were lower than those in control group (P<0.05).Conclusion：Maxing Erchen Sanzi Decoction treatment in children with acute episode of bronchial asthma can effectively improve the overall curative effects，and optimize the immune function.
Key Words Acute episode of bronchial asthma； Maxing Erchen Sanzi Decoction； Th17/Treg； Th1/Th2
中图分类号：R272.6文献标识码：Adoi：10.3969/j.issn.1673-7202.2017.10.030
哮喘是一种慢性气道炎性反应，可引起气道高反应性，急性发作时表现为喘息、气促、呼吸困难等，频繁发作可导致气道重塑及器质性呼吸系统功能改变[1-2]。中医将哮喘纳入“喘证”范畴，外因作用下痰随气升、气因痰阻，最终导致气道阻塞及哮喘急性发作[3]。目前β2受体激动剂吸入治疗哮喘最为普遍，但其控制哮喘急性发作的作用存在局限性，较多学者推荐加入中药方剂进行联合治疗。麻杏二陈三子汤具有化痰降气、止咳平喘之功效，已经在临床多种肺部疾患的治疗中获得成功应用。本次研究将麻杏二陈三子汤与常规西医治疗联合用于哮喘急性发作患儿的治疗，从整体疗效、免疫机制等方面对其作用进行探讨，现报道如下。
1 资料与方法
1.1 一般资料 选取2014年8月至2016年12月间因哮喘急性发作入院治疗的患儿90例，按照随机数表法将入组患儿分为对照组和观察组，每组45例，对照组中男25例、女20例，年龄2～8岁，平均年龄(4.18±0.59)岁，哮喘病程0.5～4年，平均病程(1.79±0.54)年；观察组中男24例、女21例，年龄2～7岁，平均年龄(4.31±0.72)岁，哮喘病程0.5～5年，平均病程(1.81±0.52)年。2组患儿的性别、年龄、哮喘病程分布差异无统计学意义(P>0.05)，本院倫理委员会讨论并批准此次研究，患儿家属签署知情同意书。, 百拇医药(刘新生 达春水 程科)
关键词 哮喘急性发作；麻杏二陈三子汤；Th17/Treg；Th1/Th2
Abstract Objective：To study the curative effects of Maxing Erchen Sanzi Decoction on children with acute episode of bronchial asthma and its influence on immune mechanism.Methods：A total of 90 children with acute episode of bronchial asthma who were treated in our hospital from August 2014 to December 2016 were selected and randomly divided into control group and observation group with 45 cases in each group according to random number table.Patients in control group were treated with routine treatment，and those in observation group were added Maxing Erchen Sanzi Decoction.The curative effects，the differences of Th17/Treg cell immunity and Th1/Th2 cell immunity between two groups were compared.Results：After treatment，the total efficiency in observation group was higher than that in control group (P<0.05)； The peripheral blood Th17 cell proportion and Th17/Treg ratio in observation group were lower than that in control group，and the proportion of Treg cells was higher than that in control group (P<0.05)； serum contents of Th1 cell factors such as IL-2 IFN-γwere higher than those in control group，and contents of Th2 cytokines such as IL-4，IL-10 were lower than those in control group (P<0.05).Conclusion：Maxing Erchen Sanzi Decoction treatment in children with acute episode of bronchial asthma can effectively improve the overall curative effects，and optimize the immune function.
Key Words Acute episode of bronchial asthma； Maxing Erchen Sanzi Decoction； Th17/Treg； Th1/Th2
中图分类号：R272.6文献标识码：Adoi：10.3969/j.issn.1673-7202.2017.10.030
哮喘是一种慢性气道炎性反应，可引起气道高反应性，急性发作时表现为喘息、气促、呼吸困难等，频繁发作可导致气道重塑及器质性呼吸系统功能改变[1-2]。中医将哮喘纳入“喘证”范畴，外因作用下痰随气升、气因痰阻，最终导致气道阻塞及哮喘急性发作[3]。目前β2受体激动剂吸入治疗哮喘最为普遍，但其控制哮喘急性发作的作用存在局限性，较多学者推荐加入中药方剂进行联合治疗。麻杏二陈三子汤具有化痰降气、止咳平喘之功效，已经在临床多种肺部疾患的治疗中获得成功应用。本次研究将麻杏二陈三子汤与常规西医治疗联合用于哮喘急性发作患儿的治疗，从整体疗效、免疫机制等方面对其作用进行探讨，现报道如下。
1 资料与方法
1.1 一般资料 选取2014年8月至2016年12月间因哮喘急性发作入院治疗的患儿90例，按照随机数表法将入组患儿分为对照组和观察组，每组45例，对照组中男25例、女20例，年龄2～8岁，平均年龄(4.18±0.59)岁，哮喘病程0.5～4年，平均病程(1.79±0.54)年；观察组中男24例、女21例，年龄2～7岁，平均年龄(4.31±0.72)岁，哮喘病程0.5～5年，平均病程(1.81±0.52)年。2组患儿的性别、年龄、哮喘病程分布差异无统计学意义(P>0.05)，本院倫理委员会讨论并批准此次研究，患儿家属签署知情同意书。, 百拇医药(刘新生 达春水 程科)