自制白及涂擦剂对上火模型(1)

http://www.100md.com 2017年6月15日 《世界中医药》 201712

     摘要 目的：观察自制白及涂擦剂对豚鼠口腔溃疡上火模型的影响。方法：采用30%冰醋酸溶液灼烧豚鼠右面颊黏膜建立口腔溃疡上火模型[1]，将建模成功后的25只豚鼠分为对照组和西药观察组、中药观察组(中药A组、中药B组、中药C组)，每组5只豚鼠，共5组，自制白及涂擦剂由白及粉、白蔹粉和丝瓜络浓煎剂组成。将涂擦剂涂在豚鼠口腔溃疡处，中药A组涂药1次/d、中药B组涂药2次/d、中药C组涂药3次/d；西药组涂金霉素眼膏2次/d，连续涂药5 d，对照组不给药；另设空白对照组豚鼠5只，涂自制白及涂擦剂，1次/d。观察不同剂量自制白及涂擦剂外用对豚鼠口腔溃疡模型溃疡面积变化、溃疡程度及溃疡局部病理组织学变化的影响。结果：用30%冰醋酸溶液造豚鼠口腔溃疡上火模型成功，与空白对照组比较，对照组口腔溃疡明显，且面积大，差异有统计学意义(P<0.05)；与对照组比较，自制白及涂擦剂可显著减小口腔溃疡面积，差异有统计学意义(P<0.01)，显著减轻局部病理变化和口腔溃疡水肿程度，差异有统计学意义(P<0.01，P<0.05)，且随着涂擦次数增多而依次减少。结论：自制白及涂擦剂对豚鼠口腔溃疡上火模型有较好的治疗作用。
, 百拇医药
    关键词 白及；白蔹；丝瓜络；口腔溃疡模型。

    Abstract Objective：To explore the external curative effect of Rhizoma Bletillae rubbing agent in oral ulceration guinea pig′s model with Shanghuo. Methods：The guinea pigs， whose right cheeks were burnt by 30% acetic acid to establish the models of oral ulceration. After successful modeling， the 25 guinea pigs were divided into model group， western medicine treatment group， Chinese medicine treatment group (Chinese medicine A group， Chinese medicine B group， Chinese medicine C group)， each group with 5 guinea pigs. Rhizoma Bletillae rubbing agent was made by Rhizoma Bletillae powder， Radix Ampelopsis powder and Retinervus Luffae Fructus Concentrated decoction. Rhizoma Bletillae rubbing agent was used on the guinea pig oral ulcers for five days. Chinese medicine A group used Rhizoma Bletillae rubbing agent once a day， while Chinese medicine B group used Rhizoma Bletillae rubbing agent twice a day， and Chinese medicine C group used Rhizoma Bletillae rubbing agent three times a day. Western medicine treatment group used Chlortetracycline eye ointment on the guinea pig oral ulcers twice a day for five days. The model group was not given treatment. The blank group of 5 guinea pigs used the Rhizoma Bletillae rubbing agent once a day. The effects of different dosages of Rhizoma Bletillae rubbing agent on oral ulcer area changes， degrees and local histopathological changes in guinea pig oral ulcer model were observed. Results：The oral ulceration in guinea pig′s model whose right cheeks were burnt by 30% acetic acid was successful. Compared with the model group， Rhizoma Bletillae rubbing agent can remarkably improve the area of ulceration and the pathological changes. Conclusion：Rhizoma Bletillae rubbing agent has remarkable external curative effect on oral ulceration guinea pig′s model.

    Key Words Rhizoma Bletillae； Radix Ampelopsis； Retinervus Luffae Fructus； Oralulcertion model

    中圖分类号：R285.6文献标识码：Adoi：10.3969/j.issn.1673-7202.2017.12.009, http://www.100md.com(杨京京 包洁 钱颖 方泽锋 肖廷枫 范永升 窦晓兵 夏永良)

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