骨质疏松症与阿尔茨海默病的相关性(5)
[26]Yaccoby S，Ling W，Zhan F，et al.Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo[J].Blood，2007，109(5)：2106-2111.
[27]Morvan F，Boulukos K，Clément-Lacroix P，et al.Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass[J].J Bone Miner Res，2006，21(6)：934-945.
[28]Fujita K，Janz S.Attenuation of WNT signaling by DKK-1 and-2 regulates BMP2-induced osteoblast differentiation and expression of OPG，RANKL and M-CSF[J].Mol Cancer，2007，6：71.
, http://www.100md.com
[29]Purro SA，Dickins EM，Salinas PC.The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss[J].J Neurosci，2012，32(10)：3492-3498.
[30]Parr C，Mirzaei N，Christian M，et al.Activation of the Wnt/β-catenin pathway represses the transcription of theβ-amyloid precursor protein cleaving enzyme(BACE1)via binding of T-cell factor-4 to BACE1 promoter[J].FASEB J，2015，29(2)：623-635.
[31]Scali C，Caraci F，Gianfriddo M，et al.Inhibition of Wnt signaling，modulation of Tau phosphorylation and induction of neuronal cell death by DKK1[J].Neurobiol Dis，2006，24(2)：254-265.
, 百拇医药
[32]Bucay N，Sarosi I，Dunstan CR，et al.osteoprotegerin-deficientmice develop early onset osteoporosis and arterial calcification[J].Genes Dev，1998，12(9)：1260-1268.
[33]Douni E，Rinotas V，Makrinou E，et al.A RANKLG278Rmutationcausing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF[J].Hum Mol Genet，2012，21(4)：784-798.
[34]Guo R，Yamashita M，Zhang Q，et al.Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins[J].J Biol Chem，2008，283(34)：23084-23092.
, http://www.100md.com
[35]吳军.阿尔茨海默病发病机理、诊断及治疗的实验研究[D].武汉：华中科技大学，2011.
[36]Li S，Yang B，Teguh D，et al.Amyloid β Peptide Enhances RANKL-Induced Osteoclast Activation through NF-κB，ERK，and Calcium Oscillation Signaling[J].Int J Mol Sci，2016，17(10).pii：E168.
[37]Li S，Liu B，Zhang L，et al.Amyloid beta peptide is elevated in osteoporoticbone tissues and enhances osteoclast function[J].Bone，2014，61：164-175.
[38]Cui S，Xiong F，Hong Y，et al.APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner[J].J Bone Miner Res，2011，26(5)：1084-1098.
[39]Zhang ND，Han T，Huang BK，et al.Traditional Chinese？medicine formulas for the treatment of osteoporosis：Implication for antiosteoporotic drug discovery[J].J Ethnopharmacol，2016，189：61-80., 百拇医药(朱音 舒冰 王拥军 王晶)
[27]Morvan F，Boulukos K，Clément-Lacroix P，et al.Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass[J].J Bone Miner Res，2006，21(6)：934-945.
[28]Fujita K，Janz S.Attenuation of WNT signaling by DKK-1 and-2 regulates BMP2-induced osteoblast differentiation and expression of OPG，RANKL and M-CSF[J].Mol Cancer，2007，6：71.
, http://www.100md.com
[29]Purro SA，Dickins EM，Salinas PC.The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss[J].J Neurosci，2012，32(10)：3492-3498.
[30]Parr C，Mirzaei N，Christian M，et al.Activation of the Wnt/β-catenin pathway represses the transcription of theβ-amyloid precursor protein cleaving enzyme(BACE1)via binding of T-cell factor-4 to BACE1 promoter[J].FASEB J，2015，29(2)：623-635.
[31]Scali C，Caraci F，Gianfriddo M，et al.Inhibition of Wnt signaling，modulation of Tau phosphorylation and induction of neuronal cell death by DKK1[J].Neurobiol Dis，2006，24(2)：254-265.
, 百拇医药
[32]Bucay N，Sarosi I，Dunstan CR，et al.osteoprotegerin-deficientmice develop early onset osteoporosis and arterial calcification[J].Genes Dev，1998，12(9)：1260-1268.
[33]Douni E，Rinotas V，Makrinou E，et al.A RANKLG278Rmutationcausing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF[J].Hum Mol Genet，2012，21(4)：784-798.
[34]Guo R，Yamashita M，Zhang Q，et al.Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins[J].J Biol Chem，2008，283(34)：23084-23092.
, http://www.100md.com
[35]吳军.阿尔茨海默病发病机理、诊断及治疗的实验研究[D].武汉：华中科技大学，2011.
[36]Li S，Yang B，Teguh D，et al.Amyloid β Peptide Enhances RANKL-Induced Osteoclast Activation through NF-κB，ERK，and Calcium Oscillation Signaling[J].Int J Mol Sci，2016，17(10).pii：E168.
[37]Li S，Liu B，Zhang L，et al.Amyloid beta peptide is elevated in osteoporoticbone tissues and enhances osteoclast function[J].Bone，2014，61：164-175.
[38]Cui S，Xiong F，Hong Y，et al.APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner[J].J Bone Miner Res，2011，26(5)：1084-1098.
[39]Zhang ND，Han T，Huang BK，et al.Traditional Chinese？medicine formulas for the treatment of osteoporosis：Implication for antiosteoporotic drug discovery[J].J Ethnopharmacol，2016，189：61-80., 百拇医药(朱音 舒冰 王拥军 王晶)