番泻苷A对慢传输型便秘大鼠肠动力的影响(1)
摘要目的：探討番泻苷A对慢传输型便秘(STC)大鼠肠动力的影响。方法：选取5周龄SD大鼠30只并随机分为对照组、模型组、番泻苷A组、番泻苷A+ZD7288组和莫沙比利组；除对照组，其余各组均用冰水灌胃法建立STC大鼠模型；以肠道炭沫推进百分率、离体结肠肌条收缩振幅和频率作为观察指标，采用电生理学法测定各组大鼠结肠肌条的电生理数据，同时通过使用超极化激活性环核苷酸门控性阳离子非选择性通道(HCN1)的特异阻断剂ZD7288观察结肠肌条电生理活动的变化。结果：番泻苷A组炭沫推进百分率高于模型组、番泻苷A+ZD7288组、莫沙必利组(P<005)；番泻苷A组的离体肌条收缩频率较模型组、番泻苷A+ZD7288组、莫沙必利组明显增多(P<005)；模型组、番泻苷A+ZD7822组与番泻苷A组比较，其离体结肠肌条收缩的振幅降低(P<005)；番泻苷A组与对照组比较，差异无统计学意义(P>005)。结论：番泻苷A通过提高大鼠肠平滑肌收缩的频率和振幅来促进肠道运动，促动力效果好于莫沙必利，HCN1离子通道可能是番泻苷A的一个作用靶点。
关键词番泻苷A；慢传输型便秘；肠动力；大鼠；HCN1通道；莫沙必利；肠平滑肌
, http://www.100md.com
Effects of Sennoside A on Intestinal Motility in Rats with Colonic Slow Transit Constipation
Li Ji1，2，Wang Jingjie2，Zhang Chao3，Zhang Rong2，Zhang Jingyu2
(1 Department of Gastroenterology，Sixth Hospital of Xi′an，Xi′an 710000，China； 2 Department of Gastroenterology，Tangdu Hospital of Air Medical University，Xi′an 710000，China； 3 Department of Gastroenterology，Third Hospital of Xi′an，Xi′an 710000，China)
, 百拇医药
AbstractObjective：To observe the effects of Sennoside A on intestinal motility in rats with colonic slow transit constipation (STC).Methods：Thirty SD rats were randomly divided into five groups：normal control group，model group，Sennoside A group，SennosideA+ZD7288 group and mosapride group.The STC rat model was established with ice water stimulation by gavage.The electrophysiology was used to detect the intestinal electrical activity.Percentage of carbon propelling，contraction amplitude and frequency of the muscle segments in vitro were observed.At the same time，the electrophysiological changes of the colonic muscle strips were observed by using the blockers of HCN1 (ZD7288)，and the data were statistically analyzed.Results：The percentage of carbon propelling in the Sennoside A group was higher than those in the model group，Sennoside A+ZD7288 group and Mosapride group (P<005).Compared with the Sennoside A group，the contraction frequency of the muscle segments in the model group，Mosapride group and Sennoside A+ZD7288 group decreased obviously (P<005).The contraction amplitude of the muscle segments in the Sennoside A group was higher than those in the model group and ZD7288+Sennoside A group (P<005).However，there was no significant difference between the Sennoside A group and the normal control group (P>005).Conclusion：Sennoside A could promote colon motility by increasing the contraction frequency and amplitude of the smooth muscle.The prokinetic effect of Sennoside A is better than mosapride.HCN1 may be a target ion channel of sennoside A., http://www.100md.com(李冀 王景杰 张超)
关键词番泻苷A；慢传输型便秘；肠动力；大鼠；HCN1通道；莫沙必利；肠平滑肌
, http://www.100md.com
Effects of Sennoside A on Intestinal Motility in Rats with Colonic Slow Transit Constipation
Li Ji1，2，Wang Jingjie2，Zhang Chao3，Zhang Rong2，Zhang Jingyu2
(1 Department of Gastroenterology，Sixth Hospital of Xi′an，Xi′an 710000，China； 2 Department of Gastroenterology，Tangdu Hospital of Air Medical University，Xi′an 710000，China； 3 Department of Gastroenterology，Third Hospital of Xi′an，Xi′an 710000，China)
, 百拇医药
AbstractObjective：To observe the effects of Sennoside A on intestinal motility in rats with colonic slow transit constipation (STC).Methods：Thirty SD rats were randomly divided into five groups：normal control group，model group，Sennoside A group，SennosideA+ZD7288 group and mosapride group.The STC rat model was established with ice water stimulation by gavage.The electrophysiology was used to detect the intestinal electrical activity.Percentage of carbon propelling，contraction amplitude and frequency of the muscle segments in vitro were observed.At the same time，the electrophysiological changes of the colonic muscle strips were observed by using the blockers of HCN1 (ZD7288)，and the data were statistically analyzed.Results：The percentage of carbon propelling in the Sennoside A group was higher than those in the model group，Sennoside A+ZD7288 group and Mosapride group (P<005).Compared with the Sennoside A group，the contraction frequency of the muscle segments in the model group，Mosapride group and Sennoside A+ZD7288 group decreased obviously (P<005).The contraction amplitude of the muscle segments in the Sennoside A group was higher than those in the model group and ZD7288+Sennoside A group (P<005).However，there was no significant difference between the Sennoside A group and the normal control group (P>005).Conclusion：Sennoside A could promote colon motility by increasing the contraction frequency and amplitude of the smooth muscle.The prokinetic effect of Sennoside A is better than mosapride.HCN1 may be a target ion channel of sennoside A., http://www.100md.com(李冀 王景杰 张超)
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