自拟壮骨饮联合钙剂治疗骨质疏松症的临床疗效及机制探讨(1)

http://www.100md.com 2018年5月15日 《世界中医药》 201810

     摘要目的：觀察用自拟壮骨饮联合钙剂对骨质疏松症患者骨密度、骨代谢生化指标的影响。方法：选取2016年1月至2017年7月达州市达川区人民医院收治经诊断为骨质疏松症患者132例，按照随机数字表法随机分为对照组和观察组，每组66例。对照组给予阿仑膦酸钠片、钙尔奇D3片治疗；观察组在此基础上给予自拟壮骨饮内服治疗，比较2组治疗效果，评价中医证候积分，监测骨密度、骨代谢生化指标变化。结果：观察组有效率为909%，明显高于对照组的788%(P<005)；观察组治疗后中医证候积分下降程度较对照组更显著(P<005)，股骨颈及L2～L4椎骨骨密度显著高于对照组(P<005)，血清Ca、BGP水平显著高于治疗前及对照组治疗后，而βCTX、ALP水平则显著低于治疗前及对照组治疗后(P<005)。结论：自拟壮骨饮联合钙剂能有效缓解临床症状，其起效机制主要在于能提高骨质疏松症患者的骨密度，促进骨形成，抗骨质疏松作用突出。

    关键词骨质疏松症；自拟壮骨饮；钙剂；骨密度；骨代谢生化指标；Ca；BGP；βCTX；ALP
, 百拇医药
    Exploration on Clinical Effects and Possible Mechanism of Action of Modified Zhuanggu Decoction Combined with Calcium on Patients with Osteoporosis

    Tan Dong，Jiang Cheng，Liu Haibo，Li Shubin，Tan Jian，Li Xiaojun，Ran Juncai，Li Jicheng，Wu Shaojun

    (Department of Orthopedics，People′s Hospital of Dazhou District，Dazhou 635000，China)

    AbstractObjective：To investigate the effects of Modified Zhuanggu Decoction combined with calcium on bone mineral density and bone metabolism biochemical indicators in patients with osteoporosis.Methods：A total of 132 patients with osteoporosis treated in People′s Hospital of Dazhou District from January 2016 to July 2017 were selected and randomly divided into control group and an observation group，with 66 cases in each group.Patients in the control group were treated with allenphosphonic acid sodium and calcium D3 pills，and patients in the observation group were given Modified Zhuanggu Decoction.The clinical efficacy was compared，and the levels change of bone mineral density and bone metabolism biochemical indicators were monitored.Results：The clinical efficacy rated in the observation group was 909%，which was significantly higher than that of the control group 788% (P<005).The TCM syndrome integrals in the observation group were decreased more than that of the control group (P<005).The femoral neck and L2L4 vertebrae bone mineral density in the observation group were increased more than that of the control group (P<005)，and the levels of serum calcium and osteocalcin increased more than that of the control group，while the levels of βCTX and alkaline phosphatase were decreased more than that of the control group (P<005).Conclusion：Modified Zhuanggu Decoction can effectively improve the patients′ bone mineral density and promote bone formation，which has outstanding antiosteoporosis effect，which is worthy of further research and development.

    Key WordsOsteoporosis； Modified Zhuanggu Decoction； Calcium supplements； Bone mineral density； Biochemical index of bone metabolism； Ca； BGP； βCTX； ALP, 百拇医药(谭东 蒋成 刘海波)

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