复方香柏颗粒外用治疗头部脂溢性皮炎的研究(1)

http://www.100md.com 2018年6月1日 《世界中医药》 201811

     摘要 目的：通过临床观察客观评价复方香柏颗粒对头部脂溢性皮炎的临床疗效，确立头部脂溢性皮炎外用药治疗的研究规范。方法：选取2017年11月至2018年6月北京中医药大学东方医院收治的头部脂溢性皮炎患者80例，随机分为观察组和对照组，每组40例，观察组外用复方香柏颗粒;对照组外用2%酮康唑洗剂。观察治疗前和治疗4周后的各症状积分及临床疗效。结果：治疗后皮损面积、红斑、鳞屑、脂溢及瘙痒等症状较治疗前均有明显改善( P <0.05)，且在鳞屑、脂溢和瘙痒方面，改善明显优于对照组( P <0.05)。2组治疗4周后，观察组40例，总有效率为90%;对照组38例，总有效率65.8%，观察组显著高于对照组( P <0.05)。结论：复方香柏颗粒外用治疗头部脂溢性皮炎疗效好，安全性高，值得临床推广使用。

    关键词 脂溢性皮炎;临床观察;酮康唑洗剂;外用;复方香柏颗粒

    Study on External Application of Compound Xiangbai Granules in the Treatment of Head Seborrheic Dermatitis
, http://www.100md.com
    Kong Yuhong 1，Jiang Yingjuan 1，Cai Lingling 1，Zhao Yajing 1，Guo Liyuan 2，Xiao Fei 3，Lin Huaner 4，Tu Shaozhong 4，Li Yuanwen 1

    (1 Dermatology Department，Dongfang Hospital Beijing University of Chinese Medicine，Beijing 100078，China; 2 Beijing University of Chinese Medicine，Beijing 100029，China; 3 Institute of Children Medicine in Jianmin Group，Wuhan 430052，China; 4 Dermatology Department of Shenzhen Hospital，Beijing University of Chinese Medicine，Shenzhen 518116，China)
, 百拇医药
    Abstract Objective： To objectively evaluate the clinical curative effect through clinical research compound Xiangbai granules in the treatment of head seborrheic dermatitis，and to establish the standard of the external treatment of head seborrheic dermatitis research specification. Methods： A total of 80 cases of head seborrheic dermatitis patients were randomly divided into two groups，treatment group (40 cases) and control group (40 cases).The patients were treated with compound Xiangbai granules in the treatment group and 2% Ketoconazole Lotion in the control group.The symptom score and clinical effects of treatment were evaluated before the treatment and after 4 weeks. Results： The symptom scores of skin lesion area，erythema，scale，seborrhea and pruritus were markedly improved than pre-treatment in the both groups (all P <0.05).After treatment of 4 weeks，treatment group (PPS) has 40 cases，and total effective rate was 90%.Control group had 38 cases，and total effective rate was 65.8%.The treatment group was markedly higher than the control group ( P <0.05). Conclusion： Compound Xiangbai granules is more effective in the treatment of head seborrheic dermatitis than that of 2% Ketoconazole Lotion，with high safety.Therefore，Compound Xiangbai granules is worthy of clinical use.

    Key Words Seborrhoeic dermatitis; Clinical observation; Ketoconazole Lotion; External use; Compound Xiangbai granules

    中圖分类号：R275.9 文献标识码：A doi： 10.3969/j.issn.1673-7202.2018.11.008, 百拇医药(孔宇虹 姜颖娟 蔡玲玲 赵雅静 郭丽媛 肖飞 林欢儿 涂绍忠 )

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