芪苈强心胶囊联合马来酸依那普利叶酸片对H型高血压患者降Hcy的疗效分析(1)
摘要 目的：探討芪苈强心胶囊联合马来酸依那普利叶酸片对H型高血压患者降同型半胱氨酸(Hcy)的疗效。方法：选取2015年8月至2017年7月达州市中心医院收治的H型高血压患者316例为研究对象，随机分为对照组和观察组，每组158例，所有患者均采用钙离子通道阻滞剂类抗高血压药物进行治疗，对照组在此基础上采用马来酸依那普利叶酸片进行治疗，观察组则采用芪苈强心胶囊联合马来酸依那普利叶酸片进行治疗，3个月为1个疗程，2组连续治疗2个疗程后进行为期12个月的随访。比较2组临床疗效;检测并比较2组患者治疗前后血压、心功能、Hcy等临床指标水平变化;记录2组治疗及随访中心脑血管事件发生率。结果：治疗后，观察组与对照组的总有效率分别为82.91%、72.15%，且观察组显著高于对照组( P <0.05)。自治疗前到治疗后12个月2组患者24 h平均SBP及DBP均逐渐降低( P <0.01)，且治疗6个月后、治疗12个月后观察组24 h平均SBP及DBP均显著低于对照组( P <0.05或 P <0.01)。治疗后2组LVEF、SV、E/A水平均较治疗前显著升高( P <0.01)，LVEDD及血浆Hcy水平均较治疗前显著下降，且2组存在显著差异( P <0.05或 P <0.01)。治疗及随访过程中观察组心血管事件发生率为5.70%，显著低于对照组的12.03%( P <0.05)。结论：芪苈强心胶囊联合马来酸依那普利叶酸片治疗H型高血压可有效控制患者血压水平，改善其心功能，降低血浆Hcy水平，临床疗效突出。
关键词 H型高血压;芪苈强心胶囊;马来酸依那普利叶酸片;疗效;同型半胱氨酸
Efficacy Analysis of Qili Qiangxin Capsules Combined with Enalapril Maleate Folic Acid Tablets in Reducing Hcy in Patients with H-type Hypertension
Li Yi，Guo Yong，Gou Hualiang，Yan Chongping，Jin Yuanying
(Department of Cardiovascular Medicine，Dazhou Central Hospital，Dazhou 635000，China)
Abstract Objective： To explore the effects of Qili Qiangxin Capsules combined with enalapril maleate folic acid tablets in reducing Hcy in patients with H-type hypertension. Methods： A total of 316 patients with H-type hypertension in Dazhou Central Hospital from August 2015 to July 2017 were randomly divided into control group ( n =158) and observation group ( n =158).All patients were treated with calcium channel blockers，on basis of which control group was treated with enalapril maleate folic acid tablets，while observation group was treated with Qili Qiangxin Capsules combined with enalapril maleate folic acid tablets.The two groups were treated for two consecutive 3-month courses and were followed up for 12 months.The clinical effects of 2 groups were compared，and the blood pressure，heart function，Hcy and other clinical indicators were detected and compared before and after treatment，and the incidence of cerebrovascular events were recorded. Results： After treatment，the total effective rates of observation group and control group were 82.91% and 72.15% respectively，and observation group was significantly higher than control group ( P <0.05); the average SBP and DBP decreased gradually in both groups at 24 h from before treatment to 12 months after treatment ( P <0.01)，and the average SBP and DBP in observation group after 6 months of treatment and after 12 months of treatment were significantly lower than those in the control group ( P <0.05 or P <0.01).Compared with before treatment，the level of LVEF，SV，E/A in 2 groups increased significantly after treatment ( P <0.01)，and the levels of LVEDD and plasma Hcy decreased significantly after treatment ( P <0.05 or P <0.01).The incidence of cardiovascular events in observation group was 5.70%，which was significantly lower than that of 12.03% in control group ( P <0.05). Conclusion： Qili Qiangxin Capsules combined with enalapril maleate folic acid tablets therapy can effectively control the blood pressure level of patients with H-type hypertension，improve the cardiac function，and reduce the level of Hcy，and the clinical effect is outstanding., http://www.100md.com(李毅 郭勇 苟华良 颜崇平 靳元英)
关键词 H型高血压;芪苈强心胶囊;马来酸依那普利叶酸片;疗效;同型半胱氨酸
Efficacy Analysis of Qili Qiangxin Capsules Combined with Enalapril Maleate Folic Acid Tablets in Reducing Hcy in Patients with H-type Hypertension
Li Yi，Guo Yong，Gou Hualiang，Yan Chongping，Jin Yuanying
(Department of Cardiovascular Medicine，Dazhou Central Hospital，Dazhou 635000，China)
Abstract Objective： To explore the effects of Qili Qiangxin Capsules combined with enalapril maleate folic acid tablets in reducing Hcy in patients with H-type hypertension. Methods： A total of 316 patients with H-type hypertension in Dazhou Central Hospital from August 2015 to July 2017 were randomly divided into control group ( n =158) and observation group ( n =158).All patients were treated with calcium channel blockers，on basis of which control group was treated with enalapril maleate folic acid tablets，while observation group was treated with Qili Qiangxin Capsules combined with enalapril maleate folic acid tablets.The two groups were treated for two consecutive 3-month courses and were followed up for 12 months.The clinical effects of 2 groups were compared，and the blood pressure，heart function，Hcy and other clinical indicators were detected and compared before and after treatment，and the incidence of cerebrovascular events were recorded. Results： After treatment，the total effective rates of observation group and control group were 82.91% and 72.15% respectively，and observation group was significantly higher than control group ( P <0.05); the average SBP and DBP decreased gradually in both groups at 24 h from before treatment to 12 months after treatment ( P <0.01)，and the average SBP and DBP in observation group after 6 months of treatment and after 12 months of treatment were significantly lower than those in the control group ( P <0.05 or P <0.01).Compared with before treatment，the level of LVEF，SV，E/A in 2 groups increased significantly after treatment ( P <0.01)，and the levels of LVEDD and plasma Hcy decreased significantly after treatment ( P <0.05 or P <0.01).The incidence of cardiovascular events in observation group was 5.70%，which was significantly lower than that of 12.03% in control group ( P <0.05). Conclusion： Qili Qiangxin Capsules combined with enalapril maleate folic acid tablets therapy can effectively control the blood pressure level of patients with H-type hypertension，improve the cardiac function，and reduce the level of Hcy，and the clinical effect is outstanding., http://www.100md.com(李毅 郭勇 苟华良 颜崇平 靳元英)