补阳还五汤治疗高脂血症的系统评价(1)

http://www.100md.com 2018年6月1日 《世界中医药》 201811

     摘要 目的：系統评价补阳还五汤治疗高脂血症的疗效和安全性;方法：计算机检索Cochrane图书馆、PubMed、Embase、CNKI、CBM、VIP、万方数据库等数据库，纳入相关RCTs，并进行评价，采用Revman5.3软件分析数据;结果：纳入6篇随机对照试验，共626例受试者。相比对照组，补阳还五汤的血脂总疗效高于对照组(RR=1.30，95%CI[1.15，1.48]， P =0.001)。治疗后总胆固醇低于对照组(WMD=-0.38，95%CI[-0.68，-0.08]， P =0.01)。治疗后三酰甘油与对照组效果接近(WMD=-0.16，95%CI[-0.44，0.12]， P =0.28)。治疗后高密度脂蛋白水平与对照组效果接近(WMD=0.05，95%CI[-0.11，0.21]， P =0.55)。治疗后低密度脂蛋白水平与对照组效果接近(WMD=0.09，95%CI[-0.64，0.82]， P =0.80)，与他汀类药物比较，补阳还五汤治疗后LDL-C水平较低(WMD=-0.48，95%CI[-0.67，-0.29]， P =0<0.00001)。纳入研究均未报道不良反应发生。结论：补阳还五汤治疗高脂血症疗效较好，对TC、TG、HDL-C、LDL-C的改善有效，对TC的改善较为明显。与他汀类药物比较，对TC、LDL-C改善较明显。
, 百拇医药
    关键词 补阳还五汤;高脂血症;系统评价;Meta分析;随机对照试验;血脂康;他汀类药物;循证医学

    Systematic Review of the Efficacy of Buyang Huanwu Decoction in Treating Hyperlipidemia

    Shi Shuai，Hu Yuanhui，Song Qingqiao，Chu Yuguang，Shi Jingjing，Wang Jiuchong

    (Guang′anmen Hospital，China Academy of Chinese Medical Sciences，Beijing 100053，China)

    Abstract Objective： To assess the efficacy and safety of Buyang Huanwu Decoction in treating hyperlipidemia. Methods： RCTs were collected by computer，using Revman5.3 software，from databases including the Cochrane library，PubMed，Embase，CNKI，CBM，VIP and Wanfang database. Results： A total of 6 RCTs were included，with 626 subjects in total.The total effect of lipid of Buyang Huanwu Decoction of the treatment group was higher than that of control group(RR=1.30，95%CI [1.15，1.48]， P =0.001).The total cholesterol(TC)level of Buyang Huanwu Decoction was lower after treatment(WMD=-0.38，95%CI [-0.68，-0.08]， P =0.01).The triglyceride(TG)level of Buyang Huanwu Decoction was indiscriminate with the control group after treatment(WMD=-0.16，95%CI [-0.44，0.12]， P =0.28).The HDL-C level of Buyang Huanwu Decoction was indiscriminate with the control group after treatment(WMD=0.05，95%CI [-0.11，0.21]， P =0.55).The level of low-density lipoprotein(LDL)was similar to that of the control group after treatment(WMD=0.09，95% CI[-0.64，0.82]， P =0.80).Compared with statins，the LDL-C level of Buyang Huanwu Decoction was lower(WMD=-0.48，95%CI [-0.67，-0.29]， P =0<0.00001).There were no relevant reports about the incidence of adverse reactions. Conclusion： Buyang Huanwu Decoction may effectively improve hyperlipidemia，including TC，TG，HDL-C and LDL-C，and especially in TC.Buyang Huanwu Decoction is more effective in the improvement of TC and LDL-C than others.It is recommended that this treatment of hyperlipidemia should be used in clinical and to add more high quality relevant studies., 百拇医药(师帅 胡元会 宋庆桥 褚瑜光 石晶晶 汪九重)

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