补肾活血法联合主动免疫治疗同种免疫型复发性流产对血清Th1和Th2细胞因子及相关激素影响的临床研究(1)
要 目的：臨床研究补肾活血法联合主动免疫治疗同种免疫型复发性流产，对血清Th1和Th2细胞因子及相关激素的影响。方法：选取2016年11月至2017年10月洛阳市第一中医院收治的同种免疫型复发性流产患者161例作为研究对象，随机分为观察组(n=82)和对照组(n=79)。观察组采取补肾活血法联合主动免疫同步治疗，对照组采用单纯给予主动免疫治疗。观察2组患者治疗前后血清Th1、Th2细胞因子与相关激素水平的变化。结果：1)Th1、Th2细胞因子水平：观察组治疗后IFN-γ(6.65±2.41)ng/L，IL-2(7.13±2.59)ng/L，IL-4(2.66±0.48)ng/L，IL-6(2.75±0.36)ng/L，及Th1/Th2(2.98±0.64)。对照组治疗后IFN-γ(12.39±2.85)ng/L，IL-2(11.84±3.51)ng/L，IL-4(1.78±0.45)ng/L，IL-6(1.57±0.23)ng/L，及Th1/Th2(7.48±2.37)。2)激素水平：观察组治疗后3周HCG(116 812.36±762.35)mIU/mL，P(28.19±3.77)ng/mL，E2(1 250.94±36.27ab)ng/L。对照组治疗后3周HCG(106016.28±725.45)mIU/mL，P(25.67±2.59)ng/mL，E2(905.81±33.02)ng/L。3)中医证候积分：观察组治疗前总积分(15.56±0.54)分和治疗后总积分(3.80±0.24)分。对照组治疗前总积分(15.61±0.39)分和治疗后总积分(8.85±0.38)分。结论：补肾活血法联合主动免疫治疗同种免疫型复发性流产临床效果显著，有利于改善孕妇的内分泌及免疫调节功能，降低流产风险，改善妊娠结局。
关键词 补肾活血法;主动免疫;同种免疫型复发性流产;Th细胞因子;激素水平;中西结合;免疫反应;临床研究
Abstract Objective：To clinically study the effects of supplementing kidney and invigorating blood method combined with active immunity on serum Th1 and Th2 cytokines and related hormones in patients with alloimmune recurrent abortion.Methods：From November 2016 to October 2017，161 patients with alloimmune recurrent abortion admitted in Luoyang No.1 Hospital of TCM were selected as research objects and randomly divided into an observation group(n=82)and a control group(n=79).The observation group was given supplementing kidney and invigorating blood method combined with simultaneous active immunity，while the control group was only treated with active immunity.The changes of serum Th1 and Th2 cytokines and related hormones in the 2 groups were observed before and after treatment.Results：1)Levels of Th1 and Th2 cytokines：in the observation group after the treatment，IFN-γ(6.65±2.41)ng/L，IL-2(7.13±2.59)ng/L，IL-4(2.66±0.48)ng/L，IL-6(2.75±0.36)ng/L and Th1/Th2(2.98±0.64); in the control group after the treatment，IFN-γ(12.39±2.85)ng/L，IL-2(11.84±3.51)ng/L，IL-4(1.78±0.45)ng· L-1，IL-6(1.57±0.23)ng/L，and Th1/Th2(7.48±2.37).2)Hormone levels：in the observation group after the 3-week treatment，HCG(116812.36±762.35)mIU/mL，P(28.19±3.77)ng/mL，and E2(1250.94±36.27)ng/L; in the control group after the 3-week treatment，HCG(106016.28±725.45)mIU/mL，P(25.67±2.59)ng/mL，and E2(905.81±33.02)ng/L.3)TCM syndrome score：the total score before and after treatment in the observation group was(15.56±0.54)and(3.80±0.24)respectively.The total score before and after treatment in the control group was(15.61±0.39)and(8.85±0.38)respectively.Conclusion：For recurrent abortion of alloimmune type，the therapy of supplementing kidney and invigorating blood method combined with active immunity is clinically effective in improving endocrine and immunomodulatory function of pregnant women.It can reduce the risk of abortion and improve the outcome of pregnancy., http://www.100md.com(王文娟 陶利利 郭敏)
关键词 补肾活血法;主动免疫;同种免疫型复发性流产;Th细胞因子;激素水平;中西结合;免疫反应;临床研究
Abstract Objective：To clinically study the effects of supplementing kidney and invigorating blood method combined with active immunity on serum Th1 and Th2 cytokines and related hormones in patients with alloimmune recurrent abortion.Methods：From November 2016 to October 2017，161 patients with alloimmune recurrent abortion admitted in Luoyang No.1 Hospital of TCM were selected as research objects and randomly divided into an observation group(n=82)and a control group(n=79).The observation group was given supplementing kidney and invigorating blood method combined with simultaneous active immunity，while the control group was only treated with active immunity.The changes of serum Th1 and Th2 cytokines and related hormones in the 2 groups were observed before and after treatment.Results：1)Levels of Th1 and Th2 cytokines：in the observation group after the treatment，IFN-γ(6.65±2.41)ng/L，IL-2(7.13±2.59)ng/L，IL-4(2.66±0.48)ng/L，IL-6(2.75±0.36)ng/L and Th1/Th2(2.98±0.64); in the control group after the treatment，IFN-γ(12.39±2.85)ng/L，IL-2(11.84±3.51)ng/L，IL-4(1.78±0.45)ng· L-1，IL-6(1.57±0.23)ng/L，and Th1/Th2(7.48±2.37).2)Hormone levels：in the observation group after the 3-week treatment，HCG(116812.36±762.35)mIU/mL，P(28.19±3.77)ng/mL，and E2(1250.94±36.27)ng/L; in the control group after the 3-week treatment，HCG(106016.28±725.45)mIU/mL，P(25.67±2.59)ng/mL，and E2(905.81±33.02)ng/L.3)TCM syndrome score：the total score before and after treatment in the observation group was(15.56±0.54)and(3.80±0.24)respectively.The total score before and after treatment in the control group was(15.61±0.39)and(8.85±0.38)respectively.Conclusion：For recurrent abortion of alloimmune type，the therapy of supplementing kidney and invigorating blood method combined with active immunity is clinically effective in improving endocrine and immunomodulatory function of pregnant women.It can reduce the risk of abortion and improve the outcome of pregnancy., http://www.100md.com(王文娟 陶利利 郭敏)