痰热清联合盐酸左氧氟沙星用于社区获得性肺炎的效果与安全性分析(1)
摘要 目的：探讨痰热清联合盐酸左氧氟沙星治疗社区获得性肺炎的效果与安全性。方法：选取2018年1月至2019年12月安庆市第一人民医院收治的社区获得性肺炎66例作为研究对象，按照随机数字表法随机分为对照组与观察组，每组33例。对照组用盐酸左氧氟沙星治疗，观察组以盐酸左氧氟沙星联合痰热清进行治疗，比较2组临床治疗效果、C反应蛋白(CRP)、炎性标志物(PCT)、不良反应、啰音消失时间、咳嗽消失时间、发热消失时间等指标。结果：治疗后，观察组治疗总有效率明显高于对照组(P<0.05);观察组CRP、PCT等指标明显低于对照组(P<0.05);观察组不良反应发生率明显低于对照组(P<0.05);观察组啰音消失时间、咳嗽消失时间、发热消失时间等明显短于对照组(P<0.05)。结论：采取盐酸左氧氟沙星联合痰热清治疗社区获得性肺炎能够获得较为理想的效果，能明显改善炎性指标，加快临床症状消失，安全性较高，有极大的推广价值。
关键词 社区获得性肺炎;盐酸左氧氟沙星;痰热清;效果;安全性
Abstract Objective：To explore and analyze the effects and safety of community-acquired pneumonia treated with Tanreqing combined with levofloxacin hydrochloride. Methods：A total of 66 community-acquired pneumonia patients treated in the First People′s Hospital of Anqing from January 2018 to December 2019 were selected as the research objects and were divided into a control group and an experimental group according to random number table， with 33 cases in each group. The control group was treated with levofloxacin hydrochloride， and the experimental group was treated with Levofloxacin hydrochloride combined with Tanreqing. The curative effects， CRP(C-reactive protein)， PCT(inflammatory markers)， adverse reactions， disappearance of snoring sounds， disappearance of cough， and disappearance of fever were compared. Results：Compared with the control group， the total effective rate of treatment in the experimental group was significantly higher(P<0.05); CRP and PCT in the experimental group were significantly lower than those in the control group(P<0.05); the incidence of adverse reactions in the experimental group was significantly lower than that in the control group(P<0.05); the disappearance time of snoring sounds， cough disappearance time， and fever disappearance time in the experimental group were significantly shorter than those in the control group(P<0.05). Conclusion：Levofloxacin hydrochloride combined with Tanreqing for community-acquired pneumonia can achieve better results， significantly improve inflammatory indicators， accelerate the disappearance of clinical symptoms， have high safety and has great promotion value.
Keywords Community-acquired pneumonia; Levofloxacin hydrochloride; Tanreqing; Effects; Safety
中图分类号：R256.19文献标识码：Adoi：10.3969/j.issn.1673-7202.2020.12.021
社区获得性肺炎属于常见的感染性肺实质炎性反应，主要是指受到致病菌的影响在入院潜伏期內发病，或者在院外受到病原菌微生物感染而获得的疾病，其发生与病毒感染、非典型病原体、细菌等因素有着密切的关系，老年人是常见的发病人群[1]。大部分社区获得性肺炎患者具有出现并发症、无典型症状、起病隐匿、免疫功能减退等基本特征，临床以呼吸困难、胸痛、咳痰、咳嗽、发热等表现为主[2]。近年来，因为滥用抗生素引起肺炎链球菌等致病菌出现耐药的情况明显增多，仅通过左氧氟沙星进行治疗无法获得理想的效果，因此，亟待寻求一种联合用药的方式，从而提高临床治愈率[3]。痰热清注射液主要是由连翘、金银花、山羊角、熊胆粉、黄芩等药物制作而成的中药制剂，具有化痰、清热解毒的功效。有研究者指出，在左氧氟沙星基础上联合痰热清注射液治疗社区获得性肺炎能够获得较为理想的效果，对改善患者治疗预后有着积极的作用[4]。本文对收治的社区获得性肺炎患者采取盐酸左氧氟沙星联合痰热清注射液治疗，并对治疗效果进行分析，报道如下。, http://www.100md.com(王智胜 赵大海)
关键词 社区获得性肺炎;盐酸左氧氟沙星;痰热清;效果;安全性
Abstract Objective：To explore and analyze the effects and safety of community-acquired pneumonia treated with Tanreqing combined with levofloxacin hydrochloride. Methods：A total of 66 community-acquired pneumonia patients treated in the First People′s Hospital of Anqing from January 2018 to December 2019 were selected as the research objects and were divided into a control group and an experimental group according to random number table， with 33 cases in each group. The control group was treated with levofloxacin hydrochloride， and the experimental group was treated with Levofloxacin hydrochloride combined with Tanreqing. The curative effects， CRP(C-reactive protein)， PCT(inflammatory markers)， adverse reactions， disappearance of snoring sounds， disappearance of cough， and disappearance of fever were compared. Results：Compared with the control group， the total effective rate of treatment in the experimental group was significantly higher(P<0.05); CRP and PCT in the experimental group were significantly lower than those in the control group(P<0.05); the incidence of adverse reactions in the experimental group was significantly lower than that in the control group(P<0.05); the disappearance time of snoring sounds， cough disappearance time， and fever disappearance time in the experimental group were significantly shorter than those in the control group(P<0.05). Conclusion：Levofloxacin hydrochloride combined with Tanreqing for community-acquired pneumonia can achieve better results， significantly improve inflammatory indicators， accelerate the disappearance of clinical symptoms， have high safety and has great promotion value.
Keywords Community-acquired pneumonia; Levofloxacin hydrochloride; Tanreqing; Effects; Safety
中图分类号：R256.19文献标识码：Adoi：10.3969/j.issn.1673-7202.2020.12.021
社区获得性肺炎属于常见的感染性肺实质炎性反应，主要是指受到致病菌的影响在入院潜伏期內发病，或者在院外受到病原菌微生物感染而获得的疾病，其发生与病毒感染、非典型病原体、细菌等因素有着密切的关系，老年人是常见的发病人群[1]。大部分社区获得性肺炎患者具有出现并发症、无典型症状、起病隐匿、免疫功能减退等基本特征，临床以呼吸困难、胸痛、咳痰、咳嗽、发热等表现为主[2]。近年来，因为滥用抗生素引起肺炎链球菌等致病菌出现耐药的情况明显增多，仅通过左氧氟沙星进行治疗无法获得理想的效果，因此，亟待寻求一种联合用药的方式，从而提高临床治愈率[3]。痰热清注射液主要是由连翘、金银花、山羊角、熊胆粉、黄芩等药物制作而成的中药制剂，具有化痰、清热解毒的功效。有研究者指出，在左氧氟沙星基础上联合痰热清注射液治疗社区获得性肺炎能够获得较为理想的效果，对改善患者治疗预后有着积极的作用[4]。本文对收治的社区获得性肺炎患者采取盐酸左氧氟沙星联合痰热清注射液治疗，并对治疗效果进行分析，报道如下。, http://www.100md.com(王智胜 赵大海)
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