仙芪扶正颗粒联合三焦针法对Ⅲ-Ⅳ期结直肠癌患者免疫及CEA、CA724的影响(1)
摘要 目的：探究仙芪扶正顆粒联合三焦针法对Ⅲ-Ⅳ期结直肠癌患者免疫功能及CEA、CA724的影响。方法：选取2018年9月至2019年9月烟台市中医医院收治的Ⅲ-Ⅳ期结直肠癌患者66例作为研究对象，随机分为观察组和对照组，每组33例。对照组接受化疗+安慰剂颗粒+安慰针法，观察组接受化疗+仙芪扶正颗粒+三焦针刺，均以14 d为1个周期，2组均治疗4个周期。比较2组患者癌因性疲乏情况、生命质量、中医症状评分、T淋巴细胞亚群、血清肿瘤标志物水平、临床疗效及不良反应。结果：治疗后，2组QLQ-C30各维度评分、CD3+、CD4+、CD4+/CD8+和血清CEA、CA724、CA19-9均升高，观察组显著高于对照组(均P<0.05)。治疗后，2组中医症状评分、CD8+均降低(P<0.05)，观察组显著低于对照组(均P<0.05);观察组DRC高于对照组(P<0.05);观察组恶心呕吐、神经毒性发生率低于对照组(均P<0.05)。结论：在化疗基础上，联用仙芪扶正颗粒及三焦针法可降低Ⅲ-Ⅳ结直肠癌患者CEA、CA724水平，改善其免疫功能，抑制不良反应，降低癌因性疲乏，提高生命质量，疗效确切。
关键词 结直肠癌;仙芪扶正颗粒;三焦针法;免疫;癌胚抗原;糖类抗原724
Abstract Objective：To investigate the effects of Xianqi Fuzheng Granule combined with Sanjiao acupuncture on immunity and CEA and CA724 in patients with Ⅲ-Ⅳ colorectal cancer.Methods：A total of 66 cases of patients with stage Ⅲ-Ⅳ colorectal cancer treated in Yantai Traditional Chinese Medicine Hospital from Sep.2018 to Sep.2019 were collected and were randomly divided into a treatment group(n=33)，and a control group(n=33).The treatment group was treated with chemotherapy+Xianqi Fuzheng Granules+Sanjiao acupuncture，and the control group was treated with chemotherapy+Xianqi Fuzheng Granules+Sanjiao acupuncture，with 14 d/cycle and 4 cycles.The cancer-related fatigue and quality of life，TCM symptom scores，T lymphocyte subset，serum tumor marker levels，efficacy，adverse reactions between the 2 groups were compared.Results：After treatment，the QLQ-C30 scores of all dimensions，CD3+，CD4+，CD4+/CD8+ and serum CEA，CA724，and CA19-9 levels in the 2 groups increased and those in the treatment group were significantly higher than those in the control group(P<0.05).After treatment，the TCM symptom score and the percentage of CD8 in the 2 groups were significantly lower than before the treatment，those in the treatment group were significantly lower than in the control group(P<0.05).The DRC of the treatment group(90.91%)was higher than that of control group(63.64%，P<0.05).The incidence of nausea，vomiting and neurotoxicity were lower in the treatment group than in the control group(33.33% vs 57.58%，36.36% vs 63.64%，P<0.05).Conclusion：Based on chemotherapy，the combination of Xianqi Fuzheng Granules and the Sanjiao acupuncture method can reduce the levels of CEA and CA724 in patients with Ⅲ-Ⅳ colorectal cancer，improve their immune function，reduce adverse reactions，cancer-related fatigue，improve quality of life，with accurate efficacy.
Keywords Colorectal cancer; Xianqi Fuzheng Granule; Sanjiao acupuncture; Immunity; Carcinoembryonic antigen; Carbohydrate antigen 724, http://www.100md.com(戴玲玲 孟鹏 毛俊俊)
关键词 结直肠癌;仙芪扶正颗粒;三焦针法;免疫;癌胚抗原;糖类抗原724
Abstract Objective：To investigate the effects of Xianqi Fuzheng Granule combined with Sanjiao acupuncture on immunity and CEA and CA724 in patients with Ⅲ-Ⅳ colorectal cancer.Methods：A total of 66 cases of patients with stage Ⅲ-Ⅳ colorectal cancer treated in Yantai Traditional Chinese Medicine Hospital from Sep.2018 to Sep.2019 were collected and were randomly divided into a treatment group(n=33)，and a control group(n=33).The treatment group was treated with chemotherapy+Xianqi Fuzheng Granules+Sanjiao acupuncture，and the control group was treated with chemotherapy+Xianqi Fuzheng Granules+Sanjiao acupuncture，with 14 d/cycle and 4 cycles.The cancer-related fatigue and quality of life，TCM symptom scores，T lymphocyte subset，serum tumor marker levels，efficacy，adverse reactions between the 2 groups were compared.Results：After treatment，the QLQ-C30 scores of all dimensions，CD3+，CD4+，CD4+/CD8+ and serum CEA，CA724，and CA19-9 levels in the 2 groups increased and those in the treatment group were significantly higher than those in the control group(P<0.05).After treatment，the TCM symptom score and the percentage of CD8 in the 2 groups were significantly lower than before the treatment，those in the treatment group were significantly lower than in the control group(P<0.05).The DRC of the treatment group(90.91%)was higher than that of control group(63.64%，P<0.05).The incidence of nausea，vomiting and neurotoxicity were lower in the treatment group than in the control group(33.33% vs 57.58%，36.36% vs 63.64%，P<0.05).Conclusion：Based on chemotherapy，the combination of Xianqi Fuzheng Granules and the Sanjiao acupuncture method can reduce the levels of CEA and CA724 in patients with Ⅲ-Ⅳ colorectal cancer，improve their immune function，reduce adverse reactions，cancer-related fatigue，improve quality of life，with accurate efficacy.
Keywords Colorectal cancer; Xianqi Fuzheng Granule; Sanjiao acupuncture; Immunity; Carcinoembryonic antigen; Carbohydrate antigen 724, http://www.100md.com(戴玲玲 孟鹏 毛俊俊)