参麦注射液对恶性肿瘤化疗患者微循环及白细胞水平的影响(1)
摘要 目的：探討参麦注射液对恶性肿瘤化疗患者微循环及白细胞水平的影响。方法：选取2016年2月至2017年1月黑龙江中医药大学附属第一医院收治的恶性肿瘤患者61例作为研究对象，按照随机数字表法随机分为对照组(n=30)和观察组(n=31)。对照组接受常规化疗，观察组在对照组基础上给予参麦注射液进行治疗。检测2组化疗前后全血T淋巴细胞亚群、血液流变学、微循环状态及白细胞水平，统计2组化疗后缓解率。结果：化疗4个周期后，对照组全血CD3+、CD4+、NK及观察组CD8+较化疗前降低，且观察组全血CD8+低于对照组(P<0.01);观察组全血CD3+、CD4+、NK及CD4+/CD8+较化疗前升高，且观察组高于对照组(P<0.01);2组全血血浆黏度、血沉、纤维蛋白原、红细胞压积及形态、管周状态、流态、综合积分较化疗前降低，且观察组低于对照组(P<0.01)。化疗1～4周期后，对照组全血白细胞计数较化疗前逐渐降低，观察组较化疗前先降低后升高，且化疗4个周期后观察组高于对照组(P<0.01)。化疗4个周期后，观察组ORR高于对照组(64.52% vs 33.33%，P<0.05)。结论：参麦注射液可改善恶性肿瘤化疗患者微循环状态，并能抑制化疗所致的白细胞减少。
关键词 恶性肿瘤;化学疗法;参麦注射液;微循环;免疫;血液流变学;白细胞水平
Abstract Objective：To explore the effects of Shenmai Injection on microcirculation and leukocyte levels of patients with malignant tumor receiving chemotherapy. Methods：A total of 61 patients with malignant tumor admitted to First Affiliated Hospital， Heilongjiang University of Chinese Medicine were selected as the research objects and were randomly divided into a control group (n=30) and an observation group (n=31) according to random number table method. The control group received conventional chemotherapy， and the observation group was treated with Shenmai Injection on the basis of the control group. The whole blood T-lymphocyte subsets， hemorheology， microcirculation status and leukocyte levels in 2 groups of patients were detected before and after chemotherapy， and the remission rate in 2 groups were statistically analyzed after chemotherapy. Results：The whole blood CD3+， CD4+ and NK proportion in control group and CD8+ proportion in observation group after 4 cycles of chemotherapy were lower than those before chemotherapy (P<0.01)， the whole blood CD8+ proportion in observation group was lower than that in control group (P<0.01); the whole blood CD3+， CD4+， NK proportion and CD4+/CD8+ in observation group were higher than those before chemotherapy， and observation group were higher than control group (P<0.01); the whole blood plasma viscosity， erythrocyte sedimentation rate， fibrinogen， hematocrit and morphology， peritubular state， fluid state， and comprehensive integral in the 2 groups were lower than those before chemotherapy， and the observation group were lower than the control group (P<0.01). After 1～4 cycles of chemotherapy， the total white blood cell count of the control group gradually decreased compared with that before chemotherapy， and the observation group first decreased and then increased. The observation group was lower than before chemotherapy and then increased， and the observation group was higher than the control group after 4 cycles of chemotherapy (P<0.01). After 4 cycles of chemotherapy， the ORR of the observation group was higher than that of the control group (64.52% vs 33.33%， P<0.05). Conclusion：Shenmai Injection could improve microcirculation status of patients with malignant tumor receiving chemotherapy， and inhibit the reduction of leukocyte caused by chemotherapy., http://www.100md.com(郝晶 孙岸弢 赵伟 杜福泉 高明洁)
关键词 恶性肿瘤;化学疗法;参麦注射液;微循环;免疫;血液流变学;白细胞水平
Abstract Objective：To explore the effects of Shenmai Injection on microcirculation and leukocyte levels of patients with malignant tumor receiving chemotherapy. Methods：A total of 61 patients with malignant tumor admitted to First Affiliated Hospital， Heilongjiang University of Chinese Medicine were selected as the research objects and were randomly divided into a control group (n=30) and an observation group (n=31) according to random number table method. The control group received conventional chemotherapy， and the observation group was treated with Shenmai Injection on the basis of the control group. The whole blood T-lymphocyte subsets， hemorheology， microcirculation status and leukocyte levels in 2 groups of patients were detected before and after chemotherapy， and the remission rate in 2 groups were statistically analyzed after chemotherapy. Results：The whole blood CD3+， CD4+ and NK proportion in control group and CD8+ proportion in observation group after 4 cycles of chemotherapy were lower than those before chemotherapy (P<0.01)， the whole blood CD8+ proportion in observation group was lower than that in control group (P<0.01); the whole blood CD3+， CD4+， NK proportion and CD4+/CD8+ in observation group were higher than those before chemotherapy， and observation group were higher than control group (P<0.01); the whole blood plasma viscosity， erythrocyte sedimentation rate， fibrinogen， hematocrit and morphology， peritubular state， fluid state， and comprehensive integral in the 2 groups were lower than those before chemotherapy， and the observation group were lower than the control group (P<0.01). After 1～4 cycles of chemotherapy， the total white blood cell count of the control group gradually decreased compared with that before chemotherapy， and the observation group first decreased and then increased. The observation group was lower than before chemotherapy and then increased， and the observation group was higher than the control group after 4 cycles of chemotherapy (P<0.01). After 4 cycles of chemotherapy， the ORR of the observation group was higher than that of the control group (64.52% vs 33.33%， P<0.05). Conclusion：Shenmai Injection could improve microcirculation status of patients with malignant tumor receiving chemotherapy， and inhibit the reduction of leukocyte caused by chemotherapy., http://www.100md.com(郝晶 孙岸弢 赵伟 杜福泉 高明洁)