陈泓志 梁伟林 顾瞻 张慧卿

    摘要 程序性细胞死亡蛋白-1及其配体(PD-1/PD-L1)抑制剂可引发与既往治疗手段不同的免疫相关不良反应。根据中医基础理论及药性理论的相关知识，尝试对PD-1/PD-L1抑制剂进行中药化性能分析，认为PD-1/PD-L1抑制剂的药物性能属辛温之品，趋向升浮，归于肺、脾、胃经，其免疫相关不良反应的主要病因为“免疫药毒”，主要病机为风邪兼杂湿邪与热毒合阻于肌肤，脾胃虚弱以及气血亏虚，并提出了相应的治法，以期对免疫治疗的临床疗效及安全性的提升起到积极作用。

    关键词 免疫治疗;免疫相关不良反应;病因分析;病机分析;中药性能

    Etiology and Pathogeny Analysis and Treatment Exploration in Traditional Chinese Medicine of Immune-related Adverse Reactions of PD-1/PD-L1 Inhibitors

    CHEN Hongzhi1， LIANG Weilin2， GU Zhan3， ZHANG Huiqing4

    (1 Basic Medicine College， Naval Medical University， Shanghai 200433， China; 2 Department of General Internal Medicine， West Medical District of Chinese PLA General Hospital， Beijing 100041， China; 3 Department of Integrative Medicine， Shanghai Pulmonary Hospital Affiliated to Tongji University， Shanghai 200433， China; 4 Department of Traditional Chinese Medicine， Naval Medical University， Shanghai 200433， China)

    Abstract Programmed cell death-1 and its ligand (PD-1/PD-L1) inhibitors could cause immune-related adverse reactions different from previous treatments. According to the relevant knowledge of traditional Chinese medicine (TCM) basic theories and medicinal property theories ......