彭菊琴 任钧国 张艺楠 李春岩

    摘要 目的：探讨单核细胞/高密度脂蛋白胆固醇比值(MHR)与冠心病血瘀证的相关性。方法：选取2018年1月至2018年7月中日友好医院收治的冠心病患者180例作为研究对象，根据冠心病血瘀证积分分为血瘀证组(n=118)和非血瘀证组(n=62)，选取同期非冠心病非血瘀证患者55例作为对照组，比较3组MHR的差异。采用Logistic回归分析MHR与冠心病血瘀证的关系;通过绘制受试者工作特征曲线(ROC)，评估MHR诊断冠心病血瘀证的能力。结果：血瘀证组MHR水平高于非血瘀证组和对照组(P0.05)。Logistic回归分析表明，MHR是冠心病血瘀证的独立危险因素(HR：0.903，95%CI为0.826～0.988，P=0.026)。ROC分析表明，MHR诊断冠心病血瘀证的最佳截止值为14.15，敏感度为83.9%，特异度为68.6%[曲线下面积(AUC)0.609，95%CI为0.521～0.696，P=0.017]。结论：MHR是冠心病血瘀证的独立危险因素，提示脂质驱动的炎症反应可能是冠心病血瘀证形成病理机制之一。

    关键词 冠心病;血瘀证;单核细胞/高密度脂蛋白胆固醇比值;炎症;脂质代谢紊乱;理化指标;诊断;相关性

    Abstract Objective：To analyze the relationship between monocyte to high-density lipoprotein cholesterol ratio(MHR)with blood-stasis syndrome(BSS)in coronary heart disease(CHD).Methods：A total of 180 CHD inpatients admitted to China-Japan Friendship Hospital from January 2018 to July 2018 were selected as the research objects and were divided into a BSS group(118 cases)and a non-BSS group(62 cases)according to the score of BSS in CHD.A total of 55 participants with non-CHD and non-BSS were recruited as control group.The levels of MHR was compared among 3 groups.Logistic regression was used to analyze the relationship between MHR and BSS score.And receiver operating characteristic(ROC)curve was drawn to evaluate the ability of MHR to diagnose BSS of coronary CHD.Results：The levels of MHR in the BSS group was significantly higher than non-BSS group and control group(P0.05).Logistic regression analysis showed that MHR was an independent risk factor for BSS in CHD [HR：0.903 ......