张敏 闫蒙蒙 陈茜楠 常茵 邢海燕

    摘要 目的：系统评价参芪地黄汤加减治疗狼疮性肾炎的有效性及安全性。方法：检索PubMed、The Cochrane Library、Embase、Wed of Science、国家知识基础设施数据库、中国学术期刊数据库、中文科技期刊数据库等数据库，收集参芪地黄汤治疗狼疮性肾炎的随机对照试验(RCT)，检索时间为建库至2020年7月。采用RevMan 5.3进行Meta分析。结果：最终纳入12项研究，共886例患者。Meta分析结果显示：观察組(参芪地黄汤联合西医常规治疗)在改善患者临床疗效，降低24 h尿蛋白定量，降低血管内皮生长因子(VEGF)，降低系统红斑狼疮疾病活动指数(SLEDAI)，提升补体C3含量等方面均优于对照组，差异有统计学意义(均 P <0.05);观察组不良反应发生情况低于对照组，差异有统计学意义( P <0.05)。结论：参芪地黄汤加减治疗狼疮性肾炎疗效明确，且不良反应少，安全性好，值得临床推广应用。

    关键词 参芪地黄汤;中医药;狼疮性肾炎;有效性;安全性;随机对照研究;系统评价;Meta分析

    A Systematic Review of the Efficacy and Safety of Shenqi Dihuang Decoction in the Treatment of Lupus Nephritis

    ZHANG Min1，YAN Mengmeng1，CHEN Qiannan1，CHANG Yin1，XING Haiyan2

    (1 Henan University of Chinese Medicine，Zhengzhou 450000，China; 2 The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China)

    AbstractObjective： To systematically review the efficacy and safety of Shenqi Dihuang Decoction in the treatment of lupus nephritis. Methods： PubMed，Cochrane Library，Embase，Wed of Science，CNKI，Wanfang Data，and VIP were searched to collect the randomized controlled trials(RCTs) on Shenqi Dihuang Decoction treating lupus nephritis from the establishment of the database to July 2020.RevMan 5.3 was used for Meta analysis. Results： Twelve studies were included ......